Serum levels and single nucleotide polymorphisms of the interleukin-33 gene in atopic dermatitis

Anna Zaryczańska; Jolanta Gleń; Monika Zabłotna; Roman Nowicki; Magdalena Trzeciak

doi:10.5114/ada.2022.113130

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

Serum levels and single nucleotide polymorphisms of the interleukin-33 gene in atopic dermatitis

Anna Zaryczańska

¹

,

Jolanta Gleń

¹

,

Monika Zabłotna

¹

,

Roman J. Nowicki

¹

,

Magdalena Trzeciak

¹

Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland

Adv Dermatol Allergol 2022; XXXIX (5): 959-964

DOI: https://doi.org/10.5114/ada.2022.113130

Online publish date: 2022/03/03

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Introduction
Interleukin 33 (IL-33) is considered significant in the pathogenesis of atopic dermatitis (AD).

Aim
To determine the correlation between the serum levels of IL-33 and single nucleotide polymorphisms of its gene in the –9894 T/C (rs1929992) and –11877 C/T (rs10975519) loci and the course of AD.

Material and methods
The study group consisted of 191 patients with AD and 168 controls.

Results
The TT genotype appeared to be most frequent in patients with severe pruritus (OR = 6.69, 95% CI: 1.24–35.99, p = 0.01).

Conclusions
The results of our study are particularly important in the light of personalized medicine and might significantly contribute to further studies in this field.

keywords:

Serum levels and single nucleotide polymorphisms of the interleukin-33 gene in atopic dermatitis

Anna Zaryczańska 1 , Jolanta Gleń 1 , Monika Zabłotna 1 , Roman J. Nowicki 1 , Magdalena Trzeciak 1

IL-33; atopic dermatitis; polymorphism

Anna Zaryczańska

¹

,

Jolanta Gleń

¹

,

Monika Zabłotna

¹

,

Roman J. Nowicki

¹

,

Magdalena Trzeciak

¹