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ISSN: 1689-832X
Journal of Contemporary Brachytherapy
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3/2020
vol. 12
 
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abstract:
Case report

Single-fraction low-energy electronic brachytherapy for conjunctival lymphoma

Gustavo R. Sarria
1
,
Carla M. Cabrera
2
,
Gustavo J. Sarria
2
,
Mario Buitrago
3
,
Paola Fuentes
2
,
Solon Serpa
3
,
Frank A. Giordano
1

  1. Department of Radiation Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
  2. Radiotherapy Department, Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru
  3. Ophthalmic Oncology Department, Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru
J Contemp Brachytherapy 2020; 12, 3: 267–272
DOI: https://doi.org/10.5114/jcb.2020.96869
Online publish date: 2020/06/30
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Introduction
Conjunctival lymphoma represents an uncommon tumor, accounting for 5-10% of total extranodal lymphomas. Although radiotherapy is a frequent treatment option, limited capacities and lack of specialized centers are common problems in Peru, forcing radiation oncologists to apply short courses of radiotherapy. Here, we report a case series of patients treated with a novel single-shot scheme. Additionally, we present a literature review of the current short-course irradiation strategies.

Cases presentation
Three cases of conjunctival marginal zone (B-cell) lymphoma (marginal zone lymphoma [MZL]/mucosa-associated lymphoid tissue [MALT]) of the fornix are presented. Following biopsy and sonographic assessment of the lesion thickness, we applied a focused single dose of 14 Gy kilovoltage brachytherapy (prescribed to the maximum thickness of the lesion). Follow-up was scheduled in quarterly intervals. After 28, 31, and 40 months of follow-up, none of the three patients treated exhibited acute or chronic toxicities and remained local or distant disease-free.

Conclusions
Single dose kilovoltage brachytherapy was effective and safe in this small cohort of patients. Based on the literature, there is an evidence that local treatment in short-course radiotherapy is effective and should be considered amongst therapeutic options for these patients; however, this novel approach should be evaluated prospectively in a larger cohort.

keywords:

electronic brachytherapy, ocular adnexa lymphoma, short-course radiotherapy

  
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