Spitz nevus and melanoma: evaluation with dermoscopy
and reflectance confocal microscopy

Anna Pogorzelska-Antkowiak; Monika Slowinska; Eleonora Farinazzo; Claudio Conforti; Marina Agozzino

doi:10.5114/ada.2023.125968

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

Spitz nevus and melanoma: evaluation with dermoscopy and reflectance confocal microscopy

Anna Pogorzelska-Antkowiak

¹

,

Monika Slowinska

²

,

Eleonora Farinazzo

³

,

Claudio Conforti

³

,

Marina Agozzino

³

EsteDerm Private Dermatology Clinic, Tychy, Poland
Military Hospital, Warsaw, Poland
Department of Dermatology, University of Trieste, Trieste, Italy

Adv Dermatol Allergol 2023; XL (3): 427–431

DOI: https://doi.org/10.5114/ada.2023.125968

Online publish date: 2023/03/21

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AMA

Pogorzelska-Antkowiak A, Slowinska M, Farinazzo E, Conforti C, Agozzino M. Spitz nevus and melanoma: evaluation with dermoscopy
and reflectance confocal microscopy. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2023;40(3):427-431. doi:10.5114/ada.2023.125968.

APA

Pogorzelska-Antkowiak, A., Slowinska, M., Farinazzo, E., Conforti, C.,  & Agozzino, M. (2023). Spitz nevus and melanoma: evaluation with dermoscopy
and reflectance confocal microscopy. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 40(3), 427-431. https://doi.org/10.5114/ada.2023.125968

Chicago

Pogorzelska-Antkowiak, Anna, Monika Slowinska, Eleonora Farinazzo, Claudio Conforti,  and Marina Agozzino. 2023. "Spitz nevus and melanoma: evaluation with dermoscopy
and reflectance confocal microscopy". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 40 (3): 427-431. doi:10.5114/ada.2023.125968.

Harvard

Pogorzelska-Antkowiak, A., Slowinska, M., Farinazzo, E., Conforti, C.,  and Agozzino, M. (2023). Spitz nevus and melanoma: evaluation with dermoscopy
and reflectance confocal microscopy. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 40(3), pp.427-431. https://doi.org/10.5114/ada.2023.125968

MLA

Pogorzelska-Antkowiak, Anna et al. "Spitz nevus and melanoma: evaluation with dermoscopy
and reflectance confocal microscopy." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 40, no. 3, 2023, pp. 427-431. doi:10.5114/ada.2023.125968.

Vancouver

Pogorzelska-Antkowiak A, Slowinska M, Farinazzo E, Conforti C, Agozzino M. Spitz nevus and melanoma: evaluation with dermoscopy
and reflectance confocal microscopy. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2023;40(3):427-431. doi:10.5114/ada.2023.125968.

Introduction:
Spitz nevi (SN) include a wide range of benign melanocytic nevi, which are controversial due to their morphologic resemblance to melanoma (MM).

Aim:
To describe dermoscopic and reflectance confocal microscopic (RCM) features of SN compared to MM and assess the RCM utility in the differential diagnosis.

Material and methods:
We performed a multicentre retrospective analysis of MM and SN evaluated with dermoscopy and reflectance confocal microscopy. Three RCM mosaics were obtained for each lesion. Nine dermoscopic and twenty-one microscopic features were assessed for each lesion.

Results:
A total of 26 lesions (15 SN and 11 MM) were included. Dermoscopically, most SN showed a “starburst” pattern. Asymmetry was marked in 8 MM. There were 6 dermoscopic features significantly more prevalent in MM than in SN. RCM showed that an atypical honeycomb pattern, atypical infiltration, and disarray of the epidermis were significant for MM. SN mostly revealed a typical honeycomb pattern. At the DEJ, most of SN had a meshwork pattern; MM revealed an atypical meshwork pattern. Atypical cells and sheet-like structures were observed in most MM.

Conclusions:
A combined approach using dermoscopy and RCM supports the differential diagnosis of SN and MM. Although our study showed some significant differences between SN and MM in RCM, further research on a larger group should be considered.

keywords:

Spitz nevus and melanoma: evaluation with dermoscopy and reflectance confocal microscopy

Anna Pogorzelska-Antkowiak 1 , Monika Slowinska 2 , Eleonora Farinazzo 3 , Claudio Conforti 3 , Marina Agozzino 3

melanoma, dermoscopy, reflectance confocal microscopy, Spitz nevus

Anna Pogorzelska-Antkowiak

¹

,

Monika Slowinska

²

,

Eleonora Farinazzo

³

,

Claudio Conforti

³

,

Marina Agozzino

³