eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications
Share:
Send email
Share:
abstract:
Original paper

The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part II: B7-1, B7-2, B7-H2, B7-H3, B7-H4, B7-H5 (VISTA), B7-H6 and B7-H7

Anna Starzyńska
1
,
Aleksandra Sejda
2
,
Łukasz Adamski
1
,
Paulina Adamska
1
,
Rafał Pęksa
3
,
Monika Sakowicz-Burkiewicz
4
,
Piotr Wychowański
5
,
Barbara A. Jereczek-Fossa
6, 7

  1. Department of Oral Surgery, Medical University of Gdansk, Gdansk, Poland
  2. Department of Pathomorphology, University of Warmia and Mazury, Olsztyn, Poland
  3. Department of Pathomorphology, Medical University of Gdansk, Gdansk, Poland
  4. Department of Molecular Medicine, Medical University of Gdansk, Gdansk, Poland
  5. Department of Oral Surgery, Medical University of Warsaw, Warsaw, Poland
  6. Division of Radiotherapy, IEO European Institute of Oncology, IRCCS, Milan, Italy
  7. Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy
Adv Dermatol Allergol
DOI: https://doi.org/10.5114/ada.2020.98523
Online publish date: 2020/10/13
View full text Get citation
 
Introduction
The most common malignant neoplasm of the oral cavity is squamous cell carcinoma. It accounts for over 95% of malignant lesions in this area and is characterised by rapid spread and distant metastases.

Aim
To collect and review the data on B7 family proteins as prognostic factors in oral squamous cell carcinoma and to describe their role in aggressive disease progression.

Material and methods
A systematic review of the literature about B7-1, B7-2, B7-H2, B7-H3, B7-H4, B7-H5 (VISTA), B7-H6 and B7-H7, was carried out, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. 9 articles published before 22 May 2020 were included in the systematic review.

Results
The biggest study group consisted of 201 patients and the smallest – 40 patients. B7-1, B7-H3, B7-H4, B7-H5, B7-H6 and B7-H7 protein expressions were prognostic factors. Overall survival was significantly associated with B7-H3, B7-H5, B7-H6 and B7-H7. Immunohistochemistry was the diagnostic method used in all the studies.

Conclusions
The data presented indicate the complexity of cellular and molecular processes related to the formation, development and invasion of oral cancer. Mutations in genes encoding the B7 family and changes in the B7 protein pathway may affect the prognosis of survival in patients with oral squamous cell carcinoma.

keywords:

squamous cell carcinoma, oral cavity, B7 antigens
FEATURED PRODUCTS
BOOKS
• Atopowe Zapalenie Skóry • Choroby alergiczne w praktyce lekarza rodzinnego • Alergologia – kompendium
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.