Biology of Sport
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ISSN: 0860-021X
Biology of Sport
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4/2022
vol. 39
 
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abstract:
Original paper

The effect of IL10 gene polymorphism on obesity parameters in highly physically active young men

Ewelina Maculewicz
1
,
Andrzej Mastalerz
1
,
Bożena Antkowiak
2
,
Oktawiusz Antkowiak
2
,
Aleksandra Garbacz
3
,
Ewa Szarska
2
,
Paweł Rusin
4
,
Anna Cywińska
5
,
Agnieszka Białek
6
,
Paweł Cięszczyk
7

  1. Faculty of Physical Education, Jozef Pilsudski University of Physical Education in Warsaw, 00-968 Warsaw, Poland
  2. Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, Poland
  3. Warsaw University of Life Sciences – SGGW, 02-787 Warsaw, Poland
  4. Institute of Biological Sciences, Cardinal Stefan Wyszynski University in Warsaw, 01-938 Warsaw, Poland
  5. Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland
  6. Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 05-552 Magdalenka, Poland
  7. Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
Biol Sport. 2022;39(4):1117–1125
DOI: https://doi.org/10.5114/biolsport.2023.118336
Online publish date: 2022/09/05
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The main aim of this study was to investigate the association between 5 polymorphisms of the interleukin 10 (IL10) gene and body composition parameters in physically active young men. A cohort of 131 young men was enrolled and the following IL10 single-nucleotide polymorphisms (SNPs) were analysed: rs1518111, rs1878672, rs3024496, rs3024498 and rs3024505. The subjects were divided into groups depending on obesity parameters: body mass index (BMI) and percentage of body fat tissue (fat %). Statistical analysis was conducted for alleles, genotypes and haplotypes, and an association between SNPs and body composition parameters was analysed using four genetic models: dominant, recessive, codominant and overdominant mode of inheritance (MOI). The only statistically significant result in polymorphisms was found for rs3024505 in the over-dominant model with BMI (p = 0.04) and with fat % (p = 0.02). The haplo.score function showed an association between BMI and CCGTA (respectively) haplotype in the additive model (score = -2.00, p = 0.04) and in the dominant model (score = -2.30, p = 0.02). The obtained results indicate a statistically significant contribution of selected IL10 polymorphisms in the regulation of body weight in physically active individuals.
keywords:

interleukin, IL10, genetic polymorphisms, haplotype, BMI, fat percentage

  
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