The influence of biphasic positive airway pressure vs. sham biphasic positive airway pressure on pulmonary function in morbidly obese patients after bariatric surgery

Aikaterini N. Alexandropoulou; Konstantinos Louis; Alexandros Papakonstantinou; Konstantinos Tzirogiannis; Elissavet Stamataki; Charis Roussos; Manos Alchanatis; Christina Gratziou; Emanouil Vagiakis; Konstantinos Roditis

doi:10.5114/ait.2019.85868

eISSN: 1731-2531
ISSN: 1642-5758

Anaesthesiology Intensive Therapy

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Original article

The influence of biphasic positive airway pressure vs. sham biphasic positive airway pressure on pulmonary function in morbidly obese patients after bariatric surgery

Aikaterini N. Alexandropoulou

¹

,

Konstantinos Louis

^{2, 3}

,

Alexandros Papakonstantinou

⁴

,

Konstantinos Tzirogiannis

⁵

,

Elissavet Stamataki

¹

,

Charis Roussos

⁶

,

Manos Alchanatis

⁷

,

Christina Gratziou

⁸

,

Emanouil Vagiakis

⁶

,

Konstantinos Roditis

^{3, 9}

Department of Anesthesiology, Evangelismos General Hospital, Athens, Greece
3rd Department of Obstetrics-Gynaecology, “Attikon” University Hospital, Medical School, National Kapodistrian University of Athens, Athens, Greece
Junior Doctors’ Network-Hellas (JDN-Hellas), Athens, Greece
Organ Transplantation Unit, 1st Department of General Surgery, Evangelismos General Hospital, Athens, Greece
2nd Department of Internal Medicine, Elpis General Hospital, Athens, Greece
Center of Sleep Disorders, Department of Critical Care and Pulmonary Services, Evangelismos General Hospital, School of Medicine, National Kapodistrian University of Athens, Athens, Greece
Sotiria Hospital of Chest Diseases, School of Medicine, National Kapodistrian University of Athens, Athens, Greece
Department of Pulmonary Medicine, Evgenidio Hospital, National Kapodistrian University of Athens, School of Medicine, Athens, Greece
Department of Vascular Surgery, Korgialeneio-Benakeio Hellenic Red Cross General Hospital, Athens, Greece

Anaesthesiol Intensive Ther 2019; 51, 2: 88–95

DOI: https://doi.org/10.5114/ait.2019.85868

Online publish date: 2019/06/16

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AMA

Alexandropoulou A, Louis K, Papakonstantinou A, et al. The influence of biphasic positive airway pressure vs. sham biphasic positive airway pressure on pulmonary function in morbidly obese patients after bariatric surgery. Anaesthesiology Intensive Therapy. 2019;51(2):88-95. doi:10.5114/ait.2019.85868.

APA

Alexandropoulou, A., Louis, K., Papakonstantinou, A., Tzirogiannis, K., Stamataki, E.,  & Roussos, C. et al. (2019). The influence of biphasic positive airway pressure vs. sham biphasic positive airway pressure on pulmonary function in morbidly obese patients after bariatric surgery. Anaesthesiology Intensive Therapy, 51(2), 88-95. https://doi.org/10.5114/ait.2019.85868

Chicago

Alexandropoulou, Aikaterini N., Konstantinos Louis, Alexandros Papakonstantinou, Konstantinos Tzirogiannis, Elissavet Stamataki, Charis Roussos,  and Manos Alchanatis et al. 2019. "The influence of biphasic positive airway pressure vs. sham biphasic positive airway pressure on pulmonary function in morbidly obese patients after bariatric surgery". Anaesthesiology Intensive Therapy 51 (2): 88-95. doi:10.5114/ait.2019.85868.

Harvard

Alexandropoulou, A., Louis, K., Papakonstantinou, A., Tzirogiannis, K., Stamataki, E., Roussos, C., Alchanatis, M., Gratziou, C., Vagiakis, E.,  and Roditis, K. (2019). The influence of biphasic positive airway pressure vs. sham biphasic positive airway pressure on pulmonary function in morbidly obese patients after bariatric surgery. Anaesthesiology Intensive Therapy, 51(2), pp.88-95. https://doi.org/10.5114/ait.2019.85868

MLA

Alexandropoulou, Aikaterini N. et al. "The influence of biphasic positive airway pressure vs. sham biphasic positive airway pressure on pulmonary function in morbidly obese patients after bariatric surgery." Anaesthesiology Intensive Therapy, vol. 51, no. 2, 2019, pp. 88-95. doi:10.5114/ait.2019.85868.

Vancouver

Alexandropoulou A, Louis K, Papakonstantinou A, Tzirogiannis K, Stamataki E, Roussos C et al. The influence of biphasic positive airway pressure vs. sham biphasic positive airway pressure on pulmonary function in morbidly obese patients after bariatric surgery. Anaesthesiology Intensive Therapy. 2019;51(2):88-95. doi:10.5114/ait.2019.85868.

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Background
The effect of biphasic positive airway pressure (BPAP) at individualized pressures on the postoperative pulmonary recovery of morbidly obese patients (MOP) undergoing open bariatric surgery (OBS) and possible placebo device-related effects (sham BPAP) were investigated.

Methods
Forty-eight MOP scheduled for OBS were initially enrolled. Subjects were randomly assigned to: A) the BPAP group in which BPAP, at individualized inspiratory positive airway pressure/expiratory positive airway pressure (IPAP/EPAP), was applied for 3 days postoperatively and B) the sham BPAP group in which sham BPAP was applied for the same time. Pulmonary function was assessed by spirometry 24 h prior to surgery and at 24, 48 and 72 h postoperatively and respiratory complications were recorded.

Results
Thirty-five subjects, 21 in the BPAP group and 14 in the sham BPAP group, completed the study. Baseline characteristics and pulmonary function were similar between groups preoperatively. Subjects in the BPAP group showed in general better spirometric performance and SpO2 values postoperatively and expedited pulmonary recovery. Atelectasis combined with respiratory distress syndrome (RDS) symptoms was observed in 21% of subjects in the sham BPAP group and one of these subjects developed lower respiratory tract infection. No respiratory complications were recorded in the BPAP group. Use of higher BPAP pressures was not associated with anastomosis leakage or disruption in any patient.

Conclusion
Use of BPAP, at individualized pressures, expedites postoperative pulmonary recovery and eliminates respiratory complications in MOP who have undergone OBS.

keywords:

The influence of biphasic positive airway pressure vs. sham biphasic positive airway pressure on pulmonary function in morbidly obese patients after bariatric surgery

Aikaterini N. Alexandropoulou 1 , Konstantinos Louis 2, 3 , Alexandros Papakonstantinou 4 , Konstantinos Tzirogiannis 5 , Elissavet Stamataki 1 , Charis Roussos 6 , Manos Alchanatis 7 , Christina Gratziou 8 , Emanouil Vagiakis 6 , Konstantinos Roditis 3, 9

anesthesia, morbid obesity, surgery, bariatric, mechanical ventilation, BPAP, postoperative complications