The potential of low-dose-rate brachytherapy with iodine-125 in the treatment of local recurrences of prostate cancer after primary high-dose-rate monotherapy

Wojciech M. Burchardt; Artur J. Chyrek; Grzegorz M. Bielęda; Adam Kluska; Ewa Burchardt; Adam Chicheł

doi:10.5114/jcb.2023.126618

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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2/2023
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abstract:

Original paper

The potential of low-dose-rate brachytherapy with iodine-125 in the treatment of local recurrences of prostate cancer after primary high-dose-rate monotherapy

Wojciech M. Burchardt

^{1, 2}

,

Artur J. Chyrek

^{1, 2}

,

Grzegorz M. Bielęda

^{2, 3}

,

Adam Kluska

¹

,

Ewa Burchardt

^{2, 4}

,

Adam Chicheł

¹

Brachytherapy Department, Greater Poland Cancer Centre, Poznań, Poland
Electroradiology Department, Poznan University of Medical Sciences, Poznań, Poland
Medical Physics Department, Greater Poland Cancer Centre, Poznań, Poland
Department of Radiotherapy and Oncological Gynecology, Greater Poland Cancer Center, Poznań, Poland

J Contemp Brachytherapy 2023; 15, 2: 103–109

DOI: https://doi.org/10.5114/jcb.2023.126618

Online publish date: 2023/04/12

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AMA

M. Burchardt W, J. Chyrek A, Bielęda G, Kluska A, Burchardt E, Chicheł A. The potential of low-dose-rate brachytherapy with iodine-125 in the treatment of local recurrences of prostate cancer after primary high-dose-rate monotherapy. Journal of Contemporary Brachytherapy. 2023;15(2):103-109. doi:10.5114/jcb.2023.126618.

APA

M. Burchardt, W., J. Chyrek, A., Bielęda, G., Kluska, A., Burchardt, E.,  & Chicheł, A. (2023). The potential of low-dose-rate brachytherapy with iodine-125 in the treatment of local recurrences of prostate cancer after primary high-dose-rate monotherapy. Journal of Contemporary Brachytherapy, 15(2), 103-109. https://doi.org/10.5114/jcb.2023.126618

Chicago

M. Burchardt, Wojciech, Artur J. Chyrek, Grzegorz M. Bielęda, Adam Kluska, Ewa Burchardt,  and Adam Chicheł. 2023. "The potential of low-dose-rate brachytherapy with iodine-125 in the treatment of local recurrences of prostate cancer after primary high-dose-rate monotherapy". Journal of Contemporary Brachytherapy 15 (2): 103-109. doi:10.5114/jcb.2023.126618.

Harvard

M. Burchardt, W., J. Chyrek, A., Bielęda, G., Kluska, A., Burchardt, E.,  and Chicheł, A. (2023). The potential of low-dose-rate brachytherapy with iodine-125 in the treatment of local recurrences of prostate cancer after primary high-dose-rate monotherapy. Journal of Contemporary Brachytherapy, 15(2), pp.103-109. https://doi.org/10.5114/jcb.2023.126618

MLA

M. Burchardt, Wojciech et al. "The potential of low-dose-rate brachytherapy with iodine-125 in the treatment of local recurrences of prostate cancer after primary high-dose-rate monotherapy." Journal of Contemporary Brachytherapy, vol. 15, no. 2, 2023, pp. 103-109. doi:10.5114/jcb.2023.126618.

Vancouver

M. Burchardt W, J. Chyrek A, Bielęda G, Kluska A, Burchardt E, Chicheł A. The potential of low-dose-rate brachytherapy with iodine-125 in the treatment of local recurrences of prostate cancer after primary high-dose-rate monotherapy. Journal of Contemporary Brachytherapy. 2023;15(2):103-109. doi:10.5114/jcb.2023.126618.

Purpose:
The incidence of local prostate cancer recurrences after monotherapy with high-dose-rate brachytherapy (HDR-BT) is low. However, a cumulated number of local recurrences during follow-up is naturally observed in highly specialized oncological centers. This retrospective study aimed to present the treatment of local recurrences after HDR-BT with low-dose-rate brachytherapy (LDR-BT).

Material and methods:
Nine patients with low- and intermediate-risk prostate cancer with a median age of 71 years (range, 59-82 years) were diagnosed with local recurrences after previous monotherapy HDR-BT, 3 × 10.5 Gy (from 2010 to 2013). Median time to biochemical recurrence was 59 months (range, 21-80 months). All patients received 145 Gy with salvage LDR-BT (iodine-125). Gastrointestinal and urological toxicities were evaluated based on patients’ records following CTCAE v. 4.0 and IPSS scales.

Results:
The median follow-up after salvage treatment was 30 months (range, 17-63 months). Local recurrences (LR) were detected in two cases, and the actuarial 2-year local control was 88%. Biochemical failure was observed in four cases. Distant metastases (DM) were observed in 2 patients. In one patient, both LR and DM were diagnosed simultaneously. Four patients had no relapse of the disease, and a 2-year disease-free survival (DSF) was 58.3%. Before salvage treatment, median IPSS scores were 6.5 points (range, 1-23 points). At the first follow-up visit, after one month, the mean IPSS score was 20 points, and at the last follow-up visit, it was 8 points (range, 1-26 points). One patient had urinary retention after treatment. There was no significant change in IPSS scores before and after the treatment (p = 0.68). Two patients had grade 1 toxicity in the gastrointestinal tract.

Conclusions:
Salvage LDR-BT for patients with prostate cancer previously treated with HDR-BT monotherapy is characterized by acceptable toxicity, and may result in local disease control.

keywords:

The potential of low-dose-rate brachytherapy with iodine-125 in the treatment of local recurrences of prostate cancer after primary high-dose-rate monotherapy

Wojciech M. Burchardt 1, 2 , Artur J. Chyrek 1, 2 , Grzegorz M. Bielęda 2, 3 , Adam Kluska 1 , Ewa Burchardt 2, 4 , Adam Chicheł 1

salvage brachytherapy, recurrence prostate cancer, LDR brachytherapy

Wojciech M. Burchardt

^{1, 2}

,

Artur J. Chyrek

^{1, 2}

,

Grzegorz M. Bielęda

^{2, 3}

,

Adam Kluska

¹

,

Ewa Burchardt

^{2, 4}

,

Adam Chicheł

¹