The role of antimicrobial peptides in chronic inflammatory skin diseases

Małgorzata Marcinkiewicz; Sławomir Majewski

doi:10.5114/pdia.2015.48066

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

1/2016
vol. 33

Send email

Copy url:

abstract:

Review paper

The role of antimicrobial peptides in chronic inflammatory skin diseases

Małgorzata Marcinkiewicz

,

Sławomir Majewski

Adv Dermatol Allergol 2016; XXXIII (1): 6–12

DOI: https://doi.org/10.5114/pdia.2015.48066

Online publish date: 2016/02/29

View full text Get citation

Antimicrobial peptides (AMPs) are effector molecules of the innate immune system of the skin. They present an activity against a broad spectrum of Gram-positive and Gram-negative bacteria as well as some fungi, parasites and enveloped viruses. Several inflammatory skin diseases including psoriasis, atopic dermatitis, acne vulgaris and rosacea are characterized by a dysregulated expression of AMPs. Antimicrobial peptides are excessively produced in lesional psoriatic scales or rosacea in contrast to the atopic skin that shows lower AMP levels when compared with psoriasis. The importance of the AMPs contribution to host immunity is indisputable as alterations in the antimicrobial peptide expression have been associated with various pathologic processes. This review discusses the biology and clinical relevance of antimicrobial peptides expressed in the skin and their role in the pathogenesis of inflammatory skin diseases.

keywords:

The role of antimicrobial peptides in chronic inflammatory skin diseases

Małgorzata Marcinkiewicz , Sławomir Majewski

antimicrobial peptides, defensin, cathelicidin, LL-37, ribonuclease, innate immunity, inflammatory skin diseases, psoriasis

Małgorzata Marcinkiewicz

,

Sławomir Majewski