The role of inflammasomes in cutaneous pathology

Magdalena Ciążyńska; Joanna Narbutt; Małgorzata Skibińska; Aleksandra Lesiak

doi:10.5114/ada.2022.113802

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Review paper

The role of inflammasomes in cutaneous pathology

Magdalena Ciążyńska

^{1, 2}

,

Joanna Narbutt

²

,

Małgorzata Skibińska

²

,

Aleksandra Lesiak

²

Department of Proliferative Diseases, Nicolaus Copernicus Multidisciplinary Centre for Oncology and Traumatology, Lodz, Poland
Department of Dermatology, Paediatric Dermatology and Oncology Clinic, Medical University of Lodz, Lodz, Poland

Adv Dermatol Allergol 2022; XXXIX (1): 39-46

DOI: https://doi.org/10.5114/ada.2022.113802

Online publish date: 2022/02/28

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Inflammasomes are large intracellular multiprotein complexes, which constitute a novel part of the innate immune system. In response to danger signals from pathogens or other harmful agents, inflammasomes assemble resulting in production of the inflammatory cytokines. We discuss recent knowledge of the role of deregulated inflammasome activity in skin pathologies such as autoinflammatory diseases as well as common skin diseases such as psoriasis and atopic dermatitis. We also present an insight into the activation and effector mechanisms of inflammasomes in skin carcinogenesis. The complex influence of inflammasome on cutaneous disorders raises new challenges and opportunities for the treatment of skin diseases.

keywords:

The role of inflammasomes in cutaneous pathology

Magdalena Ciążyńska 1, 2 , Joanna Narbutt 2 , Małgorzata Skibińska 2 , Aleksandra Lesiak 2

inflammasome, skin disease, skin cancer

Magdalena Ciążyńska

^{1, 2}

,

Joanna Narbutt

²

,

Małgorzata Skibińska

²

,

Aleksandra Lesiak

²