The role of polymorphism of interleukin 2, 10, 13 and TNF-α genes in cutaneous T-cell lymphoma pathogenesis

Boguslaw Nedoszytko; Berenika Olszewska; Jadwiga Roszkiewicz; Jolanta Glen; Monika Zabłotna; Hanna Ługowska-Umer; Roman Nowicki; Małgorzata Sokołowska-Wojdyło

doi:10.5114/ada.2016.63881

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

6/2016
vol. 33

Send email

Copy url:

abstract:

Original paper

The role of polymorphism of interleukin 2, 10, 13 and TNF-α genes in cutaneous T-cell lymphoma pathogenesis

Boguslaw Nedoszytko

,

Berenika Olszewska

,

Jadwiga Roszkiewicz

,

Jolanta Glen

,

Monika Zabłotna

,

Hanna Ługowska-Umer

,

Roman Nowicki

,

Małgorzata Sokołowska-Wojdyło

Adv Dermatol Allergol 2016; XXXIII (6): 429-434

DOI: https://doi.org/10.5114/ada.2016.63881

Online publish date: 2016/12/02

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Nedoszytko B, Olszewska B, Roszkiewicz J, et al. The role of polymorphism of interleukin 2, 10, 13 and TNF-α genes in cutaneous T-cell lymphoma pathogenesis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2016;33(6):429-434. doi:10.5114/ada.2016.63881.

APA

Nedoszytko, B., Olszewska, B., Roszkiewicz, J., Glen, J., Zabłotna, M.,  & Ługowska-Umer, H. et al. (2016). The role of polymorphism of interleukin 2, 10, 13 and TNF-α genes in cutaneous T-cell lymphoma pathogenesis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 33(6), 429-434. https://doi.org/10.5114/ada.2016.63881

Chicago

Nedoszytko, Boguslaw, Berenika Olszewska, Jadwiga Roszkiewicz, Jolanta Glen, Monika Zabłotna, Hanna Ługowska-Umer,  and Roman Nowicki et al. 2016. "The role of polymorphism of interleukin 2, 10, 13 and TNF-α genes in cutaneous T-cell lymphoma pathogenesis". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 33 (6): 429-434. doi:10.5114/ada.2016.63881.

Harvard

Nedoszytko, B., Olszewska, B., Roszkiewicz, J., Glen, J., Zabłotna, M., Ługowska-Umer, H., Nowicki, R.,  and Sokołowska-Wojdyło, M. (2016). The role of polymorphism of interleukin 2, 10, 13 and TNF-α genes in cutaneous T-cell lymphoma pathogenesis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 33(6), pp.429-434. https://doi.org/10.5114/ada.2016.63881

MLA

Nedoszytko, Boguslaw et al. "The role of polymorphism of interleukin 2, 10, 13 and TNF-α genes in cutaneous T-cell lymphoma pathogenesis." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 33, no. 6, 2016, pp. 429-434. doi:10.5114/ada.2016.63881.

Vancouver

Nedoszytko B, Olszewska B, Roszkiewicz J, Glen J, Zabłotna M, Ługowska-Umer H et al. The role of polymorphism of interleukin 2, 10, 13 and TNF-α genes in cutaneous T-cell lymphoma pathogenesis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2016;33(6):429-434. doi:10.5114/ada.2016.63881.

Introduction: As the pathogenesis of cutaneous T-cell lymphomas (CTCL) is not fully understood, inherited gene polymorphisms are considered to play a role in the development of lymphomas.

Aim: To investigate whether certain gene polymorphisms might be involved in the development of CTCL.

Material and methods: In the case-control study we compared the frequency of nine selected single nucleotide polymorphisms (SNP) of seven genes (rs1800587/–889 C/T of interleukin (IL)-1α, rs2069762/–330G/T) and rs2069763/+166G/T of IL-2, rs1800925/–1112 C/T of IL-13, rs1800896/–1082 A/G of IL-10, rs4073/–251 A/T of IL-8, rs5370/K198N, rs180054/–1370T/G of endothelin-1 and rs1800629/–308 G/A of TNF-α) in 43 CTCL and Polish cases using the amplification refractory mutation system polymerase chain reaction method.

Results: We have found that two genotypes, –330GG of IL-2 and –1112TT of IL-13 both promoter variants associated with “hypertranscription phenotype”, were over-represented in CTCL patients compared to healthy controls, and they increase the risk of malignancy development (OR = 5.82, p = 0.001 for IL-2 –330 GG, and OR = 5.67, p = 0.0024 for IL-13 –1112 TT). On the other hand, high transcription –308A allele of the TNF-α gene and –1082GG of IL-10 genotype is less frequent in lymphoma patients and has protective effects on the development of CTCL (OR = 0.45, p = 0.0466 for –308A of TNF-α, and OR = 0.35, p = 0.0329 for –1082GG of IL-10 genes).

Conclusions: Our results indicate that hypertranscription promoter variants of IL-2 and IL-13 genes could be estimated as the risk factor for development of CTCL, while TNF-α and IL-10 variants have a protective effect.

keywords:

cytokine gene polymorphisms, cutaneous T-cell lymphoma

The role of polymorphism of interleukin 2, 10, 13 and TNF-α genes in cutaneous T-cell lymphoma pathogenesis

Boguslaw Nedoszytko , Berenika Olszewska , Jadwiga Roszkiewicz , Jolanta Glen , Monika Zabłotna , Hanna Ługowska-Umer , Roman Nowicki , Małgorzata Sokołowska-Wojdyło

cytokine gene polymorphisms, cutaneous T-cell lymphoma

Boguslaw Nedoszytko

,

Berenika Olszewska

,

Jadwiga Roszkiewicz

,

Jolanta Glen

,

Monika Zabłotna

,

Hanna Ługowska-Umer

,

Roman Nowicki

,

Małgorzata Sokołowska-Wojdyło