The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part II: The Treg role in skin diseases pathogenesis

Bogusław Nedoszytko; Magdalena Lange; Małgorzata Sokołowska-Wojdyło; Joanna Renke; Piotr Trzonkowski; Michał Sobjanek; Aneta Szczerkowska-Dobosz; Marek Niedoszytko; Aleksandra Górska; Jan Romantowski; Justyna Czarny; Jarosław Skokowski; Leszek Kalinowski; Roman Nowicki

doi:10.5114/ada.2017.71105

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

5/2017
vol. 34

Send email

Copy url:

abstract:

Review paper

The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part II: The Treg role in skin diseases pathogenesis

Bogusław Nedoszytko

,

Magdalena Lange

,

Małgorzata Sokołowska-Wojdyło

,

Joanna Renke

,

Piotr Trzonkowski

,

Michał Sobjanek

,

Aneta Szczerkowska-Dobosz

,

Marek Niedoszytko

,

Aleksandra Górska

,

Jan Romantowski

,

Justyna Czarny

,

Jarosław Skokowski

,

Leszek Kalinowski

,

Roman Nowicki

Adv Dermatol Allergol 2017; XXXIV (5): 405–417

DOI: https://doi.org/10.5114/ada.2017.71105

Online publish date: 2017/10/31

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Nedoszytko B, Lange M, Sokołowska-Wojdyło M, et al. The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part II: The Treg role in skin diseases pathogenesis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2017;34(5):405-417. doi:10.5114/ada.2017.71105.

APA

Nedoszytko, B., Lange, M., Sokołowska-Wojdyło, M., Renke, J., Trzonkowski, P.,  & Sobjanek, M. et al. (2017). The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part II: The Treg role in skin diseases pathogenesis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 34(5), 405-417. https://doi.org/10.5114/ada.2017.71105

Chicago

Nedoszytko, Bogusław, Magdalena Lange, Małgorzata Sokołowska-Wojdyło, Joanna Renke, Piotr Trzonkowski, Michał Sobjanek,  and Aneta Szczerkowska-Dobosz et al. 2017. "The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part II: The Treg role in skin diseases pathogenesis". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 34 (5): 405-417. doi:10.5114/ada.2017.71105.

Harvard

Nedoszytko, B., Lange, M., Sokołowska-Wojdyło, M., Renke, J., Trzonkowski, P., Sobjanek, M., Szczerkowska-Dobosz, A., Niedoszytko, M., Górska, A., Romantowski, J., Czarny, J., Skokowski, J., Kalinowski, L.,  and Nowicki, R. (2017). The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part II: The Treg role in skin diseases pathogenesis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 34(5), pp.405-417. https://doi.org/10.5114/ada.2017.71105

MLA

Nedoszytko, Bogusław et al. "The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part II: The Treg role in skin diseases pathogenesis." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 34, no. 5, 2017, pp. 405-417. doi:10.5114/ada.2017.71105.

Vancouver

Nedoszytko B, Lange M, Sokołowska-Wojdyło M, Renke J, Trzonkowski P, Sobjanek M et al. The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part II: The Treg role in skin diseases pathogenesis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2017;34(5):405-417. doi:10.5114/ada.2017.71105.

Regulatory FOXP3+ T cells (Tregs) constitute 5% to 10% of T cells in the normal human skin. They play an important role in the induction and maintenance of immunological tolerance. The suppressive effects of these cells are exerted by various mechanisms including the direct cytotoxic effect, anti-inflammatory cytokines, metabolic disruption, and modulation of the dendritic cells function. The deficiency of Treg cells number or function are one of the basic elements of the pathogenesis of many skin diseases, such as psoriasis, atopic dermatitis, bacterial and viral infections. They also play a role in the pathogenesis of T cell lymphomas of the skin (cutaneous T cell lymphomas – CTCL), skin tumors and mastocytosis. Here, in the second part of the cycle, we describe dysfunctions of Tregs in selected skin diseases.

keywords:

The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part II: The Treg role in skin diseases pathogenesis

Bogusław Nedoszytko , Magdalena Lange , Małgorzata Sokołowska-Wojdyło , Joanna Renke , Piotr Trzonkowski , Michał Sobjanek , Aneta Szczerkowska-Dobosz , Marek Niedoszytko , Aleksandra Górska , Jan Romantowski , Justyna Czarny , Jarosław Skokowski , Leszek Kalinowski , Roman Nowicki

Treg dysfunction, selected skin diseases