Toxicity in patients treated with permanent prostate brachytherapy using intraoperatively built custom-linked seeds versus loose seeds

Luc Ollivier; Francois Lucia; Truongan Nguyen; Caroline Lucas; Vincent Bourbonne; Nicolas Boussion; Gaelle Goasduff; Georges Fournier; Olivier Pradier; Gurvan Dissaux; Antoine Valeri; Ulrike Schick

doi:10.5114/jcb.2020.101687

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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6/2020
vol. 12

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abstract:

Original paper

Toxicity in patients treated with permanent prostate brachytherapy using intraoperatively built custom-linked seeds versus loose seeds

Luc Ollivier

^{1, 2}

,

Francois Lucia

^{1, 2, 3}

,

Truongan Nguyen

⁴

,

Caroline Lucas

⁴

,

Vincent Bourbonne

^{1, 2, 3}

,

Nicolas Boussion

^{1, 3}

,

Gaelle Goasduff

¹

,

Georges Fournier

^{2, 3, 4}

,

Olivier Pradier

^{1, 2, 3}

,

Gurvan Dissaux

^{1, 2, 3}

,

Antoine Valeri

^{2, 3, 4}

,

Ulrike Schick

^{1, 2, 3}

Service de Radiothérapie, CHU Brest, Brest, France
Faculté de Médecine et des Sciences de la Santé, Université de Brest, Brest, France
LaTIM, INSERM, UMR 1101, Univ Brest, Brest, France
Service d’Urologie, CHU Brest, Brest, France

J Contemp Brachytherapy 2020; 12, 6: 547–553

DOI: https://doi.org/10.5114/jcb.2020.101687

Online publish date: 2020/12/18

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AMA

Ollivier L, Lucia F, Nguyen T, et al. Toxicity in patients treated with permanent prostate brachytherapy using intraoperatively built custom-linked seeds versus loose seeds. Journal of Contemporary Brachytherapy. 2020;12(6):547-553. doi:10.5114/jcb.2020.101687.

APA

Ollivier, L., Lucia, F., Nguyen, T., Lucas, C., Bourbonne, V.,  & Boussion, N. et al. (2020). Toxicity in patients treated with permanent prostate brachytherapy using intraoperatively built custom-linked seeds versus loose seeds. Journal of Contemporary Brachytherapy, 12(6), 547-553. https://doi.org/10.5114/jcb.2020.101687

Chicago

Ollivier, Luc, Francois Lucia, Truongan Nguyen, Caroline Lucas, Vincent Bourbonne, Nicolas Boussion,  and Gaelle Goasduff et al. 2020. "Toxicity in patients treated with permanent prostate brachytherapy using intraoperatively built custom-linked seeds versus loose seeds". Journal of Contemporary Brachytherapy 12 (6): 547-553. doi:10.5114/jcb.2020.101687.

Harvard

Ollivier, L., Lucia, F., Nguyen, T., Lucas, C., Bourbonne, V., Boussion, N., Goasduff, G., Fournier, G., Pradier, O., Dissaux, G., Valeri, A.,  and Schick, U. (2020). Toxicity in patients treated with permanent prostate brachytherapy using intraoperatively built custom-linked seeds versus loose seeds. Journal of Contemporary Brachytherapy, 12(6), pp.547-553. https://doi.org/10.5114/jcb.2020.101687

MLA

Ollivier, Luc et al. "Toxicity in patients treated with permanent prostate brachytherapy using intraoperatively built custom-linked seeds versus loose seeds." Journal of Contemporary Brachytherapy, vol. 12, no. 6, 2020, pp. 547-553. doi:10.5114/jcb.2020.101687.

Vancouver

Ollivier L, Lucia F, Nguyen T, Lucas C, Bourbonne V, Boussion N et al. Toxicity in patients treated with permanent prostate brachytherapy using intraoperatively built custom-linked seeds versus loose seeds. Journal of Contemporary Brachytherapy. 2020;12(6):547-553. doi:10.5114/jcb.2020.101687.

Purpose
Low-dose-rate brachytherapy (BT) with permanent iodine-125 radioactive seeds is a highly effective treatment option for low- and favorable intermediate-risk prostate cancer. However, optimal implantation is not always achieved due to edema or seeds loss. One way to improve seed placement is the use of stranded seeds called “intraoperatively built custom-linked seeds (IBCLS)” in an opposition to loose seeds (LS). To date, there are few data comparing toxicity rates between these two techniques. The aim of this study was to compare dosimetric parameters and toxicity rates at 2 years between both procedures in a matched-paired population.

Material and methods
Patients were considered for BT according to European guidelines. Among 548 patients treated at our institution, 105 patients in the loose seeds cohort were individually matched to 105 patients in the IBCLS group according to age, prostate volume, pre-operative international prostate symptom score (IPSS), clinical stage, and Gleason score. Erectile function was scored using the five-item international index of erectile function (IIEF-5) score. A multivariable linear mixed-effects model was applied to examine the association between total and individual scores (repeated measures) and covariates.

Results
Overall, 61 (29%) patients presented with a favorable intermediate-risk prostate cancer. There were no significant changes in IPSS over time (p = 0.57). During follow-up, the IIEF-5 was similar in the two groups, except at one month, where it was lower in the IBCLS group (10.9 vs. 6.9, p = 0.029). Also, there was no difference in grade ≥ 2 rectal toxicity. At 1 month, D_90Gy, V_150%, and V_100% were higher in the LS group compared to the IBCLS group.

Conclusions
Low-dose-rate prostate brachytherapy using IBCLS is a safe technique, with comparable toxicity profiles at 2 years compared to LS brachytherapy.

keywords:

Toxicity in patients treated with permanent prostate brachytherapy using intraoperatively built custom-linked seeds versus loose seeds

Luc Ollivier 1, 2 , Francois Lucia 1, 2, 3 , Truongan Nguyen 4 , Caroline Lucas 4 , Vincent Bourbonne 1, 2, 3 , Nicolas Boussion 1, 3 , Gaelle Goasduff 1 , Georges Fournier 2, 3, 4 , Olivier Pradier 1, 2, 3 , Gurvan Dissaux 1, 2, 3 , Antoine Valeri 2, 3, 4 , Ulrike Schick 1, 2, 3

prostate cancer, brachytherapy, loose seed, linked seed, LDR