eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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6/2020
vol. 37
 
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abstract:
Original paper

Uremic pruritus and serum brain-derived neurotrophic factor in diabetic and non-diabetic haemodialysis patients

Mirosław Śnit
1
,
Katarzyna Nabrdalik
1
,
Radosław Gawlik
2
,
Grzegorz Wystrychowski
1
,
Beata Łącka-Gaździk
1
,
Roman Kuźniewicz
1
,
Janusz Gumprecht
1
,
Tomasz Wielkoszyński
3
,
Beata Łabuz-Roszak
4
,
Władysław Grzeszczak
1

  1. Department of Internal Medicine, Diabetology and Nephrology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland
  2. Department of Internal Medicine, Allergology and Clinical Immunology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland
  3. Department of Laboratory Medicine, Pulmonology Hospital, Tarnowskie Góry, Poland
  4. Department of Basic Medical Sciences, Faculty of Health Sciences in Bytom, Medical University of Silesia in Katowice, Poland
Adv Dermatol Allergol 2020; XXXVII (6): 932–937
DOI: https://doi.org/10.5114/ada.2019.87707
Online publish date: 2019/09/04
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Introduction
Even though uremic pruritus (UP) is very troublesome for haemodialysis (HD) patients, its underlying mechanism is not fully understood.

Aim
Due to the possible role of brain-derived neurotrophic factor (BDNF) and its higher serum concentration in haemodialysis diabetic patients compared to non-diabetic ones, this study is aimed to evaluate its association with UP among diabetic and non-diabetic patients on maintenance HD.

Material and methods
A total of 94 patients were enrolled into the study. A visual analogue scale (VAS) was used to assess pruritus.

Results
No differences were found between the observed study groups in terms of BDNF serum concentration, other biochemical markers, sleep disturbances, or pruritus presentation.

Conclusions
BDNF serum concentration was not found to be associated with UP among HD patients, however further studies are worth performing on a larger group of individuals.

keywords:

brain-derived neurotrophic factor, diabetes mellitus, haemodialysis, pruritus
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