Vitamin D serum levels in multiorgan failure critically ill patients undergoing continuous renal replacement therapies

Tomasz Czarnik; Aneta Czarnik; Ryszard Gawda; Maciej Piwoda; Maciej Marszalski; Miroslaw Czuczwar

doi:10.5114/ait.2020.101008

eISSN: 1731-2531
ISSN: 1642-5758

Anaesthesiology Intensive Therapy

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5/2020
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abstract:

Original paper

Vitamin D serum levels in multiorgan failure critically ill patients undergoing continuous renal replacement therapies

Tomasz Czarnik

¹

,

Aneta Czarnik

²

,

Ryszard Gawda

¹

,

Maciej Piwoda

³

,

Maciej Marszalski

³

,

Miroslaw Czuczwar

⁴

Department of Anaesthesiology, Intensive Care, and Regional ECMO Centre, Institute of Medical Sciences, University of Opole, Poland
Department of Endocrinology, Voivodeship Hospital in Opole, Poland
Department of Anaesthesiology, Intensive Care, and Regional ECMO Centre, Opole University Hospital, Poland
2nd Department of Anaesthesiology and Critical Care, Medical University of Lublin, Poland

Anaesthesiol Intensive Ther 2020; 52, 5: 359–365

DOI: https://doi.org/10.5114/ait.2020.101008

Online publish date: 2020/11/22

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Introduction
Severe vitamin D deficiency in critically ill patients is linked to mortality. There are no scientific data regarding vitamin D status in critically ill patients undergoing continuous renal replacement therapies.

Material and methods
We aimed to measure vitamin D serum levels in critically ill patients with multiorgan failure undergoing continuous renal replacement therapies. Vitamin D serum measurements in 12-hour time intervals were performed in 20 patients undergoing continuous renal replacement therapies through continuous veno-venous haemodiafiltration (the study group). The results were then compared with the historical control group (20 patients without renal replacement therapy).

Results
In the control group the median vitamin D level initially decreased, then stabilised around the fourth and fifth measurement, after which it appeared to increase unevenly. In the study group the median vitamin D level decreased considerably, and then stabilised around the third measurement. Although the differences between groups gradually increased for the last three measurements, there was insufficient evidence to indicate that they were statistically significant (P > 0.05). Significant correlations were found between the time of measurement and the level of vitamin D in the study (R = –0.31, P = 0.0002) and control groups (R = –0.18, P = 0.0341).

Conclusions
Vitamin D serum levels decline rapidly during the course of critical illness in patients undergoing continuous renal replacement therapies. No statistically significant differences in the levels of vitamin D between the study and control groups were found.

keywords:

Vitamin D serum levels in multiorgan failure critically ill patients undergoing continuous renal replacement therapies

Tomasz Czarnik 1 , Aneta Czarnik 2 , Ryszard Gawda 1 , Maciej Piwoda 3 , Maciej Marszalski 3 , Miroslaw Czuczwar 4

vitamin D, intensive care, acute kidney injury, continuous renal replacement therapy, critical illness

Tomasz Czarnik

¹

,

Aneta Czarnik

²

,

Ryszard Gawda

¹

,

Maciej Piwoda

³

,

Maciej Marszalski

³

,

Miroslaw Czuczwar

⁴