eISSN: 2081-2841
ISSN: 1689-832X
Journal of Contemporary Brachytherapy
Current Issue Archive Supplements Articles in Press Journal Information Aims and Scope Editorial Office Editorial Board Register as Author Register as Reviewer Instructions for Authors Abstracting and indexing Subscription Advertising Information Links
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank

6/2023
vol. 15
 
Share:
Share:
abstract:
Original paper

Clinical implementation of three-dimensional standardized template-guided brachytherapy for patients with locally advanced cervical cancer

Yeqiang Tu
1, 2, 3
,
Jiahao Wang
1, 2, 3
,
Yukai Chen
1, 2, 3
,
Yuanyuan Chen
1, 2, 3
,
Qiu Tang
1, 2, 3

  1. Department of Radiation Oncology, Women’s Hospital School of Medicine Zhejiang University, China
  2. Zhejiang Provincial Clinical Research Center for Obstetrics and Gynecology, China
  3. Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, China
J Contemp Brachytherapy 2023; 15, 6: 405–413
Online publish date: 2023/12/29
View full text Get citation
 
Purpose:
Although customized three-dimensional (3D) templates have shown advantages in brachytherapy, widespread application is still full of challenges. The present work proposed the use of a commercial 3D standardized template-guided intracavitary/interstitial brachytherapy (IC/ISBT) that could provide simple and reproducible needles’ insertion.

Material and methods:
43 patients received external beam radiotherapy (EBRT) with 45-50.4 Gy and subsequent IC/ISBT with 28 Gy in 4 fractions. In terms of IC/ISBT, 24 patients were treated with 3D standardized templates (ST group), and 19 patients were treated using free-hand implantation (FH group). Consistency of implantation for all needles and dosimetric differences for target and organs at risk (OARs) were then compared between two groups.

Results:
The mean variation of tip position between insertions for needles was 1.41 mm and 2.74 mm in ST group and FH group, respectively (p < 0.001). ST group was superior in terms of dosimetric conformity index (CI) and D90 for high-risk clinical target volume (HR-CTV), significantly improving to 23.21% (p < 0.001) and 3.58% (p = 0.031) compared with FH group. The D2cc of the bladder and sigmoid in the ST group were lower than those in the FH group (p < 0.05). Meanwhile, a strong correlation between the volume of HR-CTV and its CI in the ST group (R = 0.865, p < 0.001) was found with Spearman’s correlation analysis.

Conclusions:
The implementation of 3D standardized template can potentially improve the precision and consistency in the needle insertion procedure that may replace some customized 3D templates, and achieve clinical satisfied dose distribution in IC/ISBT plans for patients with LACC.

keywords:

standardized template, free-hand implantation, IC/ISBT, LACC

 
Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.