A prospective comparison of implant quality between suture-coated seeds and uncoated seeds in prostate cancer brachytherapy

Makoto Nakiri; Naoyuki Ogasawara; Hirofumi Kurose; Kosuke Ueda; Hiroki Suekane; Katsuaki Chikui; Kiyoaki Nishihara; Keiichiro Uemura; Kazuhisa Ejima; Ryuji Hoshino; Satoshi Onishi; Keisuke Komiya; Koichiro Muraki; Chikayuki Hattori; Etsuyo Ogo; Tatsuya Ishitake; Tsukasa Igawa

doi:10.5114/jcb.2024.144175

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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abstract:

Original paper

A prospective comparison of implant quality between suture-coated seeds and uncoated seeds in prostate cancer brachytherapy

Makoto Nakiri

¹

,

Naoyuki Ogasawara

¹

,

Hirofumi Kurose

¹

,

Kosuke Ueda

¹

,

Hiroki Suekane

¹

,

Katsuaki Chikui

¹

,

Kiyoaki Nishihara

¹

,

Keiichiro Uemura

¹

,

Kazuhisa Ejima

¹

,

Ryuji Hoshino

¹

,

Satoshi Onishi

¹

,

Keisuke Komiya

¹

,

Koichiro Muraki

²

,

Chikayuki Hattori

²

,

Etsuyo Ogo

²

,

Tatsuya Ishitake

³

,

Tsukasa Igawa

¹

Department of Urology, Kurume University School of Medicine, Kurume, Japan
Department of Radiology, Kurume University School of Medicine, Kurume, Japan
Department of Environmental Medicine, Kurume University School of Medicine, Kurume, Japan

J Contemp Brachytherapy 2024; 16, 5

DOI: https://doi.org/10.5114/jcb.2024.144175

Online publish date: 2024/10/16

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Purpose:
Displacement minimization of seeds is crucial during surgery in brachytherapy; however, only a few reports have compared the operability of different seeds. TheraStrand-SL is a seed, in which TheraAGX100 is wrapped in polyglactin 910 thread, and intra-prostatic displacement is expected to be reduced compared with that of Thera-AGX100, owing to the complex shape of TheraStrand-SL. We conducted a prospective study on the operability and treatment outcomes of TheraAGX100 and TheraStrand-SL placement by a single operator.

Material and methods:
The study included 69 patients who received brachytherapy for prostate cancer. Endpoints were comparisons of intra- and post-treatment dose-volume histograms, seed displacement incidence rate, seed displacement distance, seed migration/dropout incidence rate, and adverse events incidence rate between TheraAGX100 (n = 25) and TheraStrand-SL (n = 44) groups.

Results:
The intra-prostatic displacement incidence rate was significantly lower in the TheraStrand-SL group than in the TheraAGX100 group (TheraAGX100 group: 96.0%; TheraStrand-SL group: 11.4%). Further, the intra-prostatic displacement count per case tended to be lower in the TheraStrand-SL group than in the TheraAGX100 group. Additionally, a comparison of displacement distance per case showed that the TheraStrand-SL group (2.01 mm) had a statistically significantly shorter distance than the TheraAGX100 group (9.22 mm). No significant differences between the two groups were observed in terms of migration, explanted dropout seed count, dose-volume histograms, and adverse events incidence rate.

Conclusions:
Our study demonstrated the usefulness of TheraStrand-SL against intra-prostatic displacement. We expect TheraStrand-SL to have further applications in brachytherapy, including focal therapy.

keywords:

A prospective comparison of implant quality between suture-coated seeds and uncoated seeds in prostate cancer brachytherapy

brachytherapy, prostate cancer, suture-coated seed, uncoated seed