eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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3/2022
vol. 39
 
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abstract:
Original paper

An analysis of clinical effectiveness of electrochemotherapy in the treatment of advanced metastatic malignant melanoma performed in the eastern part of Central Europe: a single-centre experience

Marcin Ziętek
1, 2
,
Maciej Nowacki
1, 3
,
Jędrzej Wierzbicki
4
,
Adam Maciejczyk
2
,
Edyta Pawlak
5
,
Rafał Matkowski
2, 6

  1. Department of Oncology, Wroclaw Medical University, Wroclaw, Poland
  2. Second Department of Surgical Oncology,, Lower Silesian Oncology, Pulmonology and Hematology Center, Wroclaw, Poland
  3. Chair of Surgical Oncology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
  4. SSG Group, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
  5. Breast Cancer Unit, Wroclaw Comprehensive Cancer Centre, Wroclaw, Poland
  6. Department of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
Adv Dermatol Allergol 2022; XXXIX (3): 559-564
DOI: https://doi.org/10.5114/ada.2022.117528
Online publish date: 2022/07/14
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Introduction
Patients with cutaneous malignant melanoma (MM), in case of non-resectability of the lesions, have only a limited pool of the available treatment options. In recent years especially electrochemotherapy (ECT) has become an increasingly important therapy in locoregionally advanced MM. Aim: In this study an analysis of the ECT treatment of locoregionally advanced malignant melanoma was presented.

Material and methods
Six ECT cycles in 5 patients were performed in the Wroclaw Comprehensive Cancer Centre. Treatment response, long-term observation, technical data downloaded from electroporator and photographs taken before and after the ECT were assessed in the analysis.

Results
In total, 200 nodules in 5 patients were treated with ECT in palliative intent. After 5 out of 6 ECT cycles, the particular clinical response has been observed. Four patients with primary unresectable lesions underwent 11 surgeries of the cutaneous metastases. In long-term follow-up in 2 patients, of whom one died 19 months after the ECT, the disease progressed and in another two, no recurrence was observed.

Conclusions
ECT is an encouraging therapy for patients in whom the recurrent cutaneous melanoma cannot be treated with other methods, however, access to this method in eastern part of Central Europe is limited. The presented study seems to confirm the usefulness of this palliative approach in a specific group of patients suffering from cutaneous MM.

keywords:

electrochemotherapy, cutaneous melanoma, electroporation, in-transit metastases
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