Comparative analysis of dosimetric 
and radiobiological models of IPSA and HIPO algorithms in combined intra-cavitary/interstitial brachytherapy for cervical cancer

Chuanjun Yan; Xianliang Wang; Aiping Wen; Jingyue Luo; Siyu Zhang; Pei Wang; Jie Li

doi:10.5114/jcb.2023.128894

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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abstract:

Original paper

Comparative analysis of dosimetric and radiobiological models of IPSA and HIPO algorithms in combined intra-cavitary/interstitial brachytherapy for cervical cancer

Chuanjun Yan

¹

,

Xianliang Wang

²

,

Aiping Wen

³

,

Jingyue Luo

²

,

Siyu Zhang

³

,

Pei Wang

²

,

Jie Li

^{1, 2}

School of Medicine, Southwest Medical University of China, Luzhou, Sichuan Province, China
Department of Radiotherapy, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China
School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China

J Contemp Brachytherapy 2023; 15, 3: 212–219

DOI: https://doi.org/10.5114/jcb.2023.128894

Online publish date: 2023/06/23

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AMA

Yan C, Wang X, Wen A, et al. Comparative analysis of dosimetric 
and radiobiological models of IPSA and HIPO algorithms in combined intra-cavitary/interstitial brachytherapy for cervical cancer. Journal of Contemporary Brachytherapy. 2023;15(3):212-219. doi:10.5114/jcb.2023.128894.

APA

Yan, C., Wang, X., Wen, A., Luo, J., Zhang, S.,  & Wang, P. et al. (2023). Comparative analysis of dosimetric 
and radiobiological models of IPSA and HIPO algorithms in combined intra-cavitary/interstitial brachytherapy for cervical cancer. Journal of Contemporary Brachytherapy, 15(3), 212-219. https://doi.org/10.5114/jcb.2023.128894

Chicago

Yan, Chuanjun, Xianliang Wang, Aiping Wen, Jingyue Luo, Siyu Zhang, Pei Wang,  and Jie Li. 2023. "Comparative analysis of dosimetric 
and radiobiological models of IPSA and HIPO algorithms in combined intra-cavitary/interstitial brachytherapy for cervical cancer". Journal of Contemporary Brachytherapy 15 (3): 212-219. doi:10.5114/jcb.2023.128894.

Harvard

Yan, C., Wang, X., Wen, A., Luo, J., Zhang, S., Wang, P.,  and Li, J. (2023). Comparative analysis of dosimetric 
and radiobiological models of IPSA and HIPO algorithms in combined intra-cavitary/interstitial brachytherapy for cervical cancer. Journal of Contemporary Brachytherapy, 15(3), pp.212-219. https://doi.org/10.5114/jcb.2023.128894

MLA

Yan, Chuanjun et al. "Comparative analysis of dosimetric 
and radiobiological models of IPSA and HIPO algorithms in combined intra-cavitary/interstitial brachytherapy for cervical cancer." Journal of Contemporary Brachytherapy, vol. 15, no. 3, 2023, pp. 212-219. doi:10.5114/jcb.2023.128894.

Vancouver

Yan C, Wang X, Wen A, Luo J, Zhang S, Wang P et al. Comparative analysis of dosimetric 
and radiobiological models of IPSA and HIPO algorithms in combined intra-cavitary/interstitial brachytherapy for cervical cancer. Journal of Contemporary Brachytherapy. 2023;15(3):212-219. doi:10.5114/jcb.2023.128894.

Purpose:
To compare inverse planning simulated annealing (IPSA) and hybrid inverse planning optimization (HIPO) using dosimetric and radiobiological models, and provide a basis for selecting the optimization method for cervical cancer.

Material and methods:
This was a retrospective study including 32 patients with radical cervical cancer. Brachytherapy treatment plans were re-optimized using IPSA, HIPO1 (with a locked uterine tube), and HIPO2 (with an unlocked uterine tube). Dosimetric data, including isodose lines, HR-CTV (D₁₀₀, V_150%, V_200%, HI, and CI), and (bladder, rectum, and intestines) D_1cc, D_2cc for organs at risk (OARs) were also collected. Additionally, TCP, NTCP, BED, and EUBED were calculated, and differences were analyzed using matched samples t-test and Friedman test.

Results:
Compared with IPSA and HIPO2, HIPO1 had better V_150% and V_200% (p < 0.05). Compared with IPSA and HIPO1, HIPO2 had better D₁₀₀ and CI (p < 0.05). The doses to the bladder D1cc (4.72 ±0.33 Gy)/D_2cc (4.47 ±0.29 Gy) and rectum D_1cc (4.50 ±0.61 Gy)/D_2cc (4.11 ±0.63 Gy) were lower in HIPO2 than in IPSA and HIPO1. EUBEDs for HR-CTV were higher in HIPO1 and HIPO2 than in IPSA by 1.39-1.63%. However, TCPs were not remarkably different among the three plans (p > 0.05). Also, the NTCP for the bladder was lower in HIPO2 than in IPSA and HIPO1 by 13.04% and 16.67%, respectively.

Conclusions:
Although the dosimetric parameters of IPSA, HIPO1, and HIPO2 are comparable, HIPO2 provides better dose conformability and lower NTCP. Therefore, HIPO2 is recommended as an optimization algorithm in IC/ISBT for cervical cancer.

keywords:

Comparative analysis of dosimetric and radiobiological models of IPSA and HIPO algorithms in combined intra-cavitary/interstitial brachytherapy for cervical cancer

Chuanjun Yan 1 , Xianliang Wang 2 , Aiping Wen 3 , Jingyue Luo 2 , Siyu Zhang 3 , Pei Wang 2 , Jie Li 1, 2

cervical cancer, intra-cavitary/interstitial brachytherapy, IPSA, HIPO, EUBED, TCP/NTCP

Chuanjun Yan

¹

,

Xianliang Wang

²

,

Aiping Wen

³

,

Jingyue Luo

²

,

Siyu Zhang

³

,

Pei Wang

²

,

Jie Li

^{1, 2}