Comparison of olopatadine with ketotifen for allergic
conjunctivitis: a meta-analysis study

Shiyu Liu; Shenquan Zhong

doi:10.5114/ada.2023.127647

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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2/2023
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abstract:

Original paper

Comparison of olopatadine with ketotifen for allergic conjunctivitis: a meta-analysis study

Shiyu Liu

,

Shenquan Zhong

¹

The First People’s Hospital of Chongqing Liangjiang New Area, Chongqing, China

Adv Dermatol Allergol 2023; XL (2): 326-330

DOI: https://doi.org/10.5114/ada.2023.127647

Online publish date: 2023/05/31

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Introduction:
Allergic conjunctivitis is one of the most common non-traumatic extraocular inflammatory diseases.

Aim:
Allergic conjunctivitis is one of the most common non-traumatic extraocular inflammatory diseases.

Material and methods:
PubMed, Embase, Web of Science, EBSCO, and Cochrane library databases were systematically searched, and we included randomized controlled trials (RCTs) assessing the effect of olopatadine versus ketotifen on efficacy in patients with allergic conjunctivitis. Seven RCTs were included in the meta-analysis.

Results:
Overall, compared with ketotifen intervention for allergic conjunctivitis, olopatadine intervention was associated with substantially lower hyperaemia (mean difference (MD) = –0.77; 95% confidence interval (CI) = –1.24 to –0.30; p = 0.001), but demonstrated no significant impact on itching, tearing or papillae.

Conclusions:
These suggested that olopatadine may be more effective to relieve the symptoms of allergic conjunctivitis than ketotifen.

keywords:

Comparison of olopatadine with ketotifen for allergic conjunctivitis: a meta-analysis study

Shiyu Liu , Shenquan Zhong 1

allergic conjunctivitis, olopatadine, ketotifen, meta-analysis

Shiyu Liu

,

Shenquan Zhong

¹