Comparison of serum concentrations of interleukins 10, 12, 17 and 35 between patients with alopecia areata
and controls

Marta Wojciechowska-Zdrojowy; Alina Jankowska-Konsur; Danuta Nowicka-Suszko; Jacek Szepietowski; Anita Hryncewicz-Gwóźdź

doi:10.5114/ada.2021.112278

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

6/2021
vol. 38

Send email

Copy url:

abstract:

Original paper

Comparison of serum concentrations of interleukins 10, 12, 17 and 35 between patients with alopecia areata and controls

Marta Wojciechowska-Zdrojowy

¹

,

Alina Jankowska-Konsur

¹

,

Danuta Nowicka-Suszko

¹

,

Jacek C. Szepietowski

¹

,

Anita Hryncewicz-Gwóźdź

¹

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland

Adv Dermatol Allergol 2021; XXXVIII (6): 1052-1057

DOI: https://doi.org/10.5114/ada.2021.112278

Online publish date: 2022/01/07

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Wojciechowska-Zdrojowy M, Jankowska-Konsur A, Nowicka-Suszko D, Szepietowski JC, Hryncewicz-Gwóźdź A. Comparison of serum concentrations of interleukins 10, 12, 17 and 35 between patients with alopecia areata
and controls. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2021;38(6):1052-1057. doi:10.5114/ada.2021.112278.

APA

Wojciechowska-Zdrojowy, M., Jankowska-Konsur, A., Nowicka-Suszko, D., Szepietowski, J. C.,  & Hryncewicz-Gwóźdź, A. (2021). Comparison of serum concentrations of interleukins 10, 12, 17 and 35 between patients with alopecia areata
and controls. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 38(6), 1052-1057. https://doi.org/10.5114/ada.2021.112278

Chicago

Wojciechowska-Zdrojowy, Marta, Alina Jankowska-Konsur, Danuta Nowicka-Suszko, Jacek C Szepietowski,  and Anita Hryncewicz-Gwóźdź. 2021. "Comparison of serum concentrations of interleukins 10, 12, 17 and 35 between patients with alopecia areata
and controls". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 38 (6): 1052-1057. doi:10.5114/ada.2021.112278.

Harvard

Wojciechowska-Zdrojowy, M., Jankowska-Konsur, A., Nowicka-Suszko, D., Szepietowski, J.,  and Hryncewicz-Gwóźdź, A. (2021). Comparison of serum concentrations of interleukins 10, 12, 17 and 35 between patients with alopecia areata
and controls. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 38(6), pp.1052-1057. https://doi.org/10.5114/ada.2021.112278

MLA

Wojciechowska-Zdrojowy, Marta et al. "Comparison of serum concentrations of interleukins 10, 12, 17 and 35 between patients with alopecia areata
and controls." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 38, no. 6, 2021, pp. 1052-1057. doi:10.5114/ada.2021.112278.

Vancouver

Wojciechowska-Zdrojowy M, Jankowska-Konsur A, Nowicka-Suszko D, Szepietowski J, Hryncewicz-Gwóźdź A. Comparison of serum concentrations of interleukins 10, 12, 17 and 35 between patients with alopecia areata
and controls. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2021;38(6):1052-1057. doi:10.5114/ada.2021.112278.

Introduction
Alopecia areata (AA) is one of the most common causes of non-scarring hair loss in adults and children with unknown etiopathogenesis, however immunological factors play an important role.

Aim
To evaluate the concentration of interleukin (IL) 10 (IL-10), IL-12, IL-17 and IL-35 in the blood serum of patients with AA.

Material and methods
AA study group consisted of 118 patients. The control group consisted of 54 healthy individuals. The severity of the disease was assessed by SALT score. In the study group, the percentage of hair loss averaged 49.6% ±36.3%. The concentration of IL-10, IL-12, IL-17 and IL-35 in the serum was assessed by the enzyme-linked immunosorbent assays (ELISA).

Results
In patients with AA, the level of IL-12 and IL-17 was significantly higher than in the control group (p > 0.05). The level of IL-10 in patients was slightly higher, whereas the level of IL-35 was slightly lower, compared to the control group, but those differences were not statistically significant. Furthermore, in patients with more severe disease the IL-12 level was significantly higher as compared to patients with the less severe AA (p < 0.05).

Conclusions
The etiopathogenesis of AA is complex, however Th1 and Th17 lymphocytes and their increased activity are undoubtedly significant contributors in this process. Disorders of immunological processes in AA require further research in order to understand the underlying pathomechanisms of the disease and to provide potential therapeutic strategies.

keywords:

Comparison of serum concentrations of interleukins 10, 12, 17 and 35 between patients with alopecia areata and controls

Marta Wojciechowska-Zdrojowy 1 , Alina Jankowska-Konsur 1 , Danuta Nowicka-Suszko 1 , Jacek C. Szepietowski 1 , Anita Hryncewicz-Gwóźdź 1

alopecia areata, IL-10, IL-12, IL-17, IL-35

Marta Wojciechowska-Zdrojowy

¹

,

Alina Jankowska-Konsur

¹

,

Danuta Nowicka-Suszko

¹

,

Jacek C. Szepietowski

¹

,

Anita Hryncewicz-Gwóźdź

¹