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eISSN: 2719-3209
ISSN: 0023-2157
Klinika Oczna / Acta Ophthalmologica Polonica
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2/2005
vol. 107
 
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abstract:
Original paper

IFN-γ in tear fluid in patients with cystic fibrosis

Małgo­rza­ta Mru­ga­cz
1
,
Be­ata Żela­zow­ska
2
,
Alina Bakunowicz-Łazarczyk
1
,
Jo­lan­ta Wy­soc­ka
2
,
Ali­na Mi­na­row­ska
3

  1. Klinika Okulistyki Dziecięcej Akademii Medycznej w Białymstoku
  2. Zakład Laboratoryjnej Diagnostyki Pediatrycznej Akademii Medycznej w Białymstoku
  3. III Klinika Chorób Dzieci Akademii Medycznej w Białymstoku
Klinika Oczna 2005, 107(4-6): 287-288
Online publish date: 2005/07/02
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Introduction
To evaluate IFN-γ concentration in tear fluid in CF patients.

Material and methods
Tear samples were collected from 15 CF patients at the age 10-21, and from 15 patients in control group at the age 11-20. Cytokine levels were determined by ELISA.

Results
The concentration of IFN-γ in tear fluid in CF patients was 10.75±2.23 pg/ml, and 4.06±0.57 pg/ml in control group.

Conclusions
The results of this study indicate that increased concentration of IFN-γ in the tear fluid may be an important factor in the pathogenesis of dry eye in CF patients. They also open new perspectives related to therapeutic management.

keywords:

cystic fibrosis, interferon-gamma

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