Molecular mechanism of vasculogenic mimicry in tumors

Wen Li; Jianrong Liu; Jianlin Ren; Qi Li; Feng Gang Hou

eISSN: 2084-9850
ISSN: 1897-3116

Pielęgniarstwo Chirurgiczne i Angiologiczne/Surgical and Vascular Nursing

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1/2015
vol. 9

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abstract:

Molecular mechanism of vasculogenic mimicry in tumors

Wen Li

,

Jianrong Liu

,

Jianlin Ren

,

Qi Li

,

Feng Gang Hou

Pielęgniarstwo Chirurgiczne i Angiologiczne 2015; 1: 22–27

Online publish date: 2015/03/13

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Vasculogenic mimicry (VM) is a new model of tumor angiogenesis, which refers to the de novo formation of perfusable, matrix-rich, vasculogenic-like networks by virtue of the plasticity of aggressive tumor cells and the reconstruction of extracellular matrix (ECM). However, little is known about the molecular underpinnings of this phenomenon. To sum up, interactions of the critical VM-modulating pathways such as vascular (VE-cadherin, EphA2, VEGFR), embryonic and/or stem cell (Nodal, Notch4, CD133+, CD271), and hypoxia-related (HIF-1α, Twist1) signaling pathways are necessary for the formation of vasculogenic mimicry. What is more, accompanied by anti-angiogenic therapy of tumors, the use of VM is becoming more and more important.

keywords:

Molecular mechanism of vasculogenic mimicry in tumors

Wen Li , Jianrong Liu , Jianlin Ren , Qi Li , Feng Gang Hou

vasculogenic mimicry (VM), molecular mechanism, tumors

Wen Li

,

Jianrong Liu

,

Jianlin Ren

,

Qi Li

,

Feng Gang Hou