Salvage high-dose-rate interventional radiotherapy (brachytherapy) for locally relapsed prostate cancer after radical prostatectomy and subsequent external irradiation

Tamer Soror; Corrina Melchert; Dirk Rades; Axel S. Merseburger; György Kovács

doi:10.5114/jcb.2023.128845

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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3/2023
vol. 15

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abstract:

Original paper

Salvage high-dose-rate interventional radiotherapy (brachytherapy) for locally relapsed prostate cancer after radical prostatectomy and subsequent external irradiation

Tamer Soror

^{1, 2}

,

Corrina Melchert

¹

,

Dirk Rades

¹

,

Axel S. Merseburger

³

,

György Kovács

⁴

Radiation Oncology Department, University of Lübeck/UKSH-CL, Lübeck, Germany
National Cancer Institute (NCI), Radiation Oncology Department, Cairo University, Egypt
Department of Urology, Campus Lübeck, University Hospital Schleswig-Holstein, Lübeck, Germany
Università Cattolica del Sacro Cuore, Gemelli-INTERACTS, Rome, Italy

J Contemp Brachytherapy 2023; 15, 3: 159–165

DOI: https://doi.org/10.5114/jcb.2023.128845

Online publish date: 2023/06/21

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AMA

Soror T, Melchert C, Rades D, Merseburger A, Kovács G. Salvage high-dose-rate interventional radiotherapy (brachytherapy) for locally relapsed prostate cancer after radical prostatectomy and subsequent external irradiation. Journal of Contemporary Brachytherapy. 2023;15(3):159-165. doi:10.5114/jcb.2023.128845.

APA

Soror, T., Melchert, C., Rades, D., Merseburger, A.,  & Kovács, G. (2023). Salvage high-dose-rate interventional radiotherapy (brachytherapy) for locally relapsed prostate cancer after radical prostatectomy and subsequent external irradiation. Journal of Contemporary Brachytherapy, 15(3), 159-165. https://doi.org/10.5114/jcb.2023.128845

Chicago

Soror, Tamer, Corrina Melchert, Dirk Rades, Axel S. Merseburger,  and György Kovács. 2023. "Salvage high-dose-rate interventional radiotherapy (brachytherapy) for locally relapsed prostate cancer after radical prostatectomy and subsequent external irradiation". Journal of Contemporary Brachytherapy 15 (3): 159-165. doi:10.5114/jcb.2023.128845.

Harvard

Soror, T., Melchert, C., Rades, D., Merseburger, A.,  and Kovács, G. (2023). Salvage high-dose-rate interventional radiotherapy (brachytherapy) for locally relapsed prostate cancer after radical prostatectomy and subsequent external irradiation. Journal of Contemporary Brachytherapy, 15(3), pp.159-165. https://doi.org/10.5114/jcb.2023.128845

MLA

Soror, Tamer et al. "Salvage high-dose-rate interventional radiotherapy (brachytherapy) for locally relapsed prostate cancer after radical prostatectomy and subsequent external irradiation." Journal of Contemporary Brachytherapy, vol. 15, no. 3, 2023, pp. 159-165. doi:10.5114/jcb.2023.128845.

Vancouver

Soror T, Melchert C, Rades D, Merseburger A, Kovács G. Salvage high-dose-rate interventional radiotherapy (brachytherapy) for locally relapsed prostate cancer after radical prostatectomy and subsequent external irradiation. Journal of Contemporary Brachytherapy. 2023;15(3):159-165. doi:10.5114/jcb.2023.128845.

Purpose:
To report the use of high-dose-rate (HDR) interventional radiotherapy (brachytherapy, IRT) as a salvage treatment for macroscopic histologically confirmed local relapse of prostatic cancer after prostatectomy and subsequent external irradiation.

Material and methods:
A retrospective study of patients with prostate adenocarcinoma, treated with HDR-IRT for an isolated local relapse after prostatectomy and external irradiation at our institution (2010-2020). Treatment results and treatment related-toxicity were recorded. Clinical outcomes were analyzed.

Results:
Ten patients were identified. The median age was 63 years (range, 59-74 years), and the median follow-up time was 34 months (range, 10-68 months). Four patients had a biochemical relapse, and the mean time to prostate specific antigen (PSA) increase was 13 months. One-year biochemical failure-free survival (bFFS), 3-year bFFS, and 4-year bFFS were 80%, 60%, and 60%, respectively. Most of the treatment-related toxicities were grade 1-2. Two patients experienced grade 3 late genitourinary toxicity.

Conclusions:
HDR-IRT seems to be an effective treatment option showing acceptable toxicity for prostate cancer patients with isolated macroscopic histologically confirmed local relapse after prostatectomy and subsequent external irradiation.

keywords:

Salvage high-dose-rate interventional radiotherapy (brachytherapy) for locally relapsed prostate cancer after radical prostatectomy and subsequent external irradiation

Tamer Soror 1, 2 , Corrina Melchert 1 , Dirk Rades 1 , Axel S. Merseburger 3 , György Kovács 4

interventional radiotherapy, high-dose-rate brachytherapy, prostate cancer, biochemical failure

Tamer Soror

^{1, 2}

,

Corrina Melchert

¹

,

Dirk Rades

¹

,

Axel S. Merseburger

³

,

György Kovács

⁴