The effects of hydroxyethyl starch and gelatine 
on lung tissue and coagulation during the resuscitation 
of rats with traumatic haemorrhagic shock

Ayten Saracoglu; Kemal Saracoglu; Ilyas Ergun; Mehmet Yildirim; Metehan Akca; Cumaali Demirtas; Sermin Tetik

doi:10.5114/ait.2022.121519

eISSN: 1731-2531
ISSN: 1642-5758

Anaesthesiology Intensive Therapy

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abstract:

Original paper

The effects of hydroxyethyl starch and gelatine on lung tissue and coagulation during the resuscitation of rats with traumatic haemorrhagic shock

Ayten Saracoglu

¹

,

Kemal Tolga Saracoglu

²

,

Ilyas Samet Ergun

³

,

Mehmet Yildirim

⁴

,

Metehan Akca

⁵

,

Cumaali Demirtas

⁴

,

Sermin Tetik

⁶

Department of Anaesthesiology and Intensive Care, Marmara University School of Medicine, Marmara, Turkey
Department of Anaesthesiology and Intensive Care, University of Health Sciences Kartal Dr. Lutfi Kirdar City Hospital, Istanbul, Turkey
Department of Medical Services and Techniques, Bezmi Alem Medical School, Istanbul, Turkey
Department of Physiology, Hamidiye Faculty of Medicine, University of Health Sciences, Istanbul, Turkey
Electroneurophysiology Program, Hamidiye Vocational School of Health Services, University of Health Sciences, Istanbul, Turkey
Department of Biochemistry, Marmara University Medical School, Istanbul, Turkey

Anaesthesiol Intensive Ther 2022; 54, 5: 393–401

DOI: https://doi.org/10.5114/ait.2022.121519

Online publish date: 2022/11/30

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AMA

Saracoglu A, Saracoglu KT, Ergun IS, et al. The effects of hydroxyethyl starch and gelatine 
on lung tissue and coagulation during the resuscitation 
of rats with traumatic haemorrhagic shock. Anaesthesiology Intensive Therapy. 2022;54(5):393-401. doi:10.5114/ait.2022.121519.

APA

Saracoglu, A., Saracoglu, K. T., Ergun, I. S., Yildirim, M., Akca, M.,  & Demirtas, C. et al. (2022). The effects of hydroxyethyl starch and gelatine 
on lung tissue and coagulation during the resuscitation 
of rats with traumatic haemorrhagic shock. Anaesthesiology Intensive Therapy, 54(5), 393-401. https://doi.org/10.5114/ait.2022.121519

Chicago

Saracoglu, Ayten, Kemal T Saracoglu, Ilyas S Ergun, Mehmet Yildirim, Metehan Akca, Cumaali Demirtas,  and Sermin Tetik. 2022. "The effects of hydroxyethyl starch and gelatine 
on lung tissue and coagulation during the resuscitation 
of rats with traumatic haemorrhagic shock". Anaesthesiology Intensive Therapy 54 (5): 393-401. doi:10.5114/ait.2022.121519.

Harvard

Saracoglu, A., Saracoglu, K., Ergun, I., Yildirim, M., Akca, M., Demirtas, C.,  and Tetik, S. (2022). The effects of hydroxyethyl starch and gelatine 
on lung tissue and coagulation during the resuscitation 
of rats with traumatic haemorrhagic shock. Anaesthesiology Intensive Therapy, 54(5), pp.393-401. https://doi.org/10.5114/ait.2022.121519

MLA

Saracoglu, Ayten et al. "The effects of hydroxyethyl starch and gelatine 
on lung tissue and coagulation during the resuscitation 
of rats with traumatic haemorrhagic shock." Anaesthesiology Intensive Therapy, vol. 54, no. 5, 2022, pp. 393-401. doi:10.5114/ait.2022.121519.

Vancouver

Saracoglu A, Saracoglu K, Ergun I, Yildirim M, Akca M, Demirtas C et al. The effects of hydroxyethyl starch and gelatine 
on lung tissue and coagulation during the resuscitation 
of rats with traumatic haemorrhagic shock. Anaesthesiology Intensive Therapy. 2022;54(5):393-401. doi:10.5114/ait.2022.121519.

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Introduction
This study was constructed to compare the effects of resuscitation with gelatine and hydroxyethyl starch (HES) on coagulopathy, haemodynamics, and tissue damage during an uncontrolled haemorrhagic shock model in rats.

Material and methods
Twenty 6-month-old Sprague-Dawley rats were included in the study and divided into 4 groups. There was no haemorrhage in the sham group. The others were randomised into haemorrhage without volume replacement (control group), haemorrhage and gelatine (group G), and haemorrhage and HES (group V). Blood samples for thromboelastogram and annexin 5 values were obtained before bleeding and after resuscitation.

Results
In the control group, R (16.18 ± 2.74) and K (5.8 ± 1.1) were significantly higher than in all other groups (P = 0.001), and the TEG alpha angle was 39.54 ± 5.94°, which was found to be significantly lower than in the sham group (P = 0.001). In group V, the TEG MA value was found to be significantly lower at 30.54 ± 8.89 (P = 0.001). The annexin A5 value was significantly higher in the control group, group V, and group G than in the sham group and was highest in the control group (P = 0.001). Lung damage score measurement was 0.60 ± 0.19 in the control group, higher than in the gelatine and HES groups (P = 0.001).

Conclusions
Lung tissue damage and coagulation were positively affected by HES or gelatine resuscitation. A reduction in clot formation in the HES group might be observed due to the possible negative effect on platelets. Therefore, we concluded that the use of gelatine might be advantageous until blood transfusion is initiated in traumatic haemorrhagic shock.

keywords:

The effects of hydroxyethyl starch and gelatine on lung tissue and coagulation during the resuscitation of rats with traumatic haemorrhagic shock

Ayten Saracoglu 1 , Kemal Tolga Saracoglu 2 , Ilyas Samet Ergun 3 , Mehmet Yildirim 4 , Metehan Akca 5 , Cumaali Demirtas 4 , Sermin Tetik 6

haemorrhage, haemorrhagic shock, rat model, trauma, coagulopathy

Ayten Saracoglu

¹

,

Kemal Tolga Saracoglu

²

,

Ilyas Samet Ergun

³

,

Mehmet Yildirim

⁴

,

Metehan Akca

⁵

,

Cumaali Demirtas

⁴

,

Sermin Tetik

⁶