eISSN: 1731-2515
ISSN: 0209-1712
Anestezjologia Intensywna Terapia
Bieżący numer Archiwum O czasopiśmie Rada naukowa Recenzenci Prenumerata Kontakt Zasady publikacji prac
Panel Redakcyjny
Zgłaszanie i recenzowanie prac online
2/2019
vol. 51
 
Poleć ten artykuł:
Udostępnij:
Artykuł oryginalny

The influence of biphasic positive airway pressure vs. sham biphasic positive airway pressure on pulmonary function in morbidly obese patients after bariatric surgery

Aikaterini N. Alexandropoulou
1
,
Konstantinos Louis
2, 3
,
Alexandros Papakonstantinou
4
,
Konstantinos Tzirogiannis
5
,
Elissavet Stamataki
1
,
Charis Roussos
6
,
Manos Alchanatis
7
,
Christina Gratziou
8
,
Emanouil Vagiakis
6
,
Konstantinos Roditis
3, 9

  1. Department of Anesthesiology, Evangelismos General Hospital, Athens, Greece
  2. 3rd Department of Obstetrics-Gynaecology, “Attikon” University Hospital, Medical School, National Kapodistrian University of Athens, Athens, Greece
  3. Junior Doctors’ Network-Hellas (JDN-Hellas), Athens, Greece
  4. Organ Transplantation Unit, 1st Department of General Surgery, Evangelismos General Hospital, Athens, Greece
  5. 2nd Department of Internal Medicine, Elpis General Hospital, Athens, Greece
  6. Center of Sleep Disorders, Department of Critical Care and Pulmonary Services, Evangelismos General Hospital, School of Medicine, National Kapodistrian University of Athens, Athens, Greece
  7. Sotiria Hospital of Chest Diseases, School of Medicine, National Kapodistrian University of Athens, Athens, Greece
  8. Department of Pulmonary Medicine, Evgenidio Hospital, National Kapodistrian University of Athens, School of Medicine, Athens, Greece
  9. Department of Vascular Surgry, Korgialeneio-Benakeio Hellenic Red Cross General Hospital, Athens, Greece
Anestezjologia Intensywna Terapia 2019; 51, 2: 92–99
Data publikacji online: 2019/07/16
Plik artykułu:
Pobierz cytowanie
 
 
Obesity is a systemic disease that affects respiratory function significantly, leading to the emergence of restrictive lung disease [1]. The already compromised respiratory function in obese individuals is further aggravated by abdominal surgery, as in the case of bariatric surgery, a fact that exponentially increases the risk of postoperative pulmonary complications [2, 3].
Anesthesia, pain and surgical manipulations also contribute to the aggravation of pulmonary function postoperatively. Meticulous management of anesthetic drugs, adequate analgesia, advanced surgical techniques and respiratory physiotherapy have all been reported to exert a positive effect on postoperative respiratory function [4-8].
The biphasic positive airway pressure (BPAP) system combines inspiratory support (inspiratory positive airway pressure – IPAP) with expiratory support (expiratory positive airway pressure – EPAP) and has been used, with good results, in a number of different clinical conditions such as chronic obstructive pulmonary disease (COPD), respiratory failure due to neuromuscular disease, cardiogenic pulmonary edema, and immediately post-operatively with prophylactic intent [9–11].
Despite the observed beneficial effects of BPAP in diverse clinical settings, there is a lack of randomized placebo-controlled trials using sham BPAP to compare different treatment options and neutralize any possible confounding results from device application.
In the present study we investigated the effect of BPAP on the postoperative respiratory function and related complications of morbidly obese patients (MOP) undergoing open bariatric surgery (OBS) through a randomized sham-controlled design. BPAP was applied at individualized pressures in order to optimize respiratory support and sham BPAP was also used in order to neutralize a possible placebo device related effect and researcher related bias.
We hypothesized that the use of BPAP at individualized pressures in MOP undergoing OBS ameliorates postoperative respiratory function as well as diminishing related pulmonary complications, postoperative pain and duration of hospitalization. Our primary endpoints were the difference in pre- and postoperative measurements of certain pulmonary function parameters: forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), peak expiratory flow rate (PEFR) and SpO2 and the incidence of certain pulmonary complications postoperatively (hypoxemia, atelectasis, lower respiratory tract infections). Secondary endpoints were postoperative pain and days of hospitalization.

Methods

Τhis prospective randomized single-blinded study with a control group was conducted in a tertiary urban Greek hospital. The study, registered at www.clinicaltrials.gov (identifier: NCT03438383), received approval by the Scientific Board of the Evangelismos General Hospital, Athens, Greece (Pr.n. 142/23-5-11) abiding to the Greek Law for invasive clinical studies in humans and conforming to standards set out in the Declaration of Helsinki of the World Medical Association. Forty-eight Caucasian MOP, 24 male and 24 female, were initially enrolled and written informed consent explaining the specifics of the protocol and the treatment involved was obtained from all subjects. All subjects had been morbidly obese (body mass index – BMI > 40 kg m-2) for at least 10 years and had unsuccessfully tried to lose weight by other non-invasive means. Exclusion criteria included cardiovascular and pulmonary disease not related to obesity status, and chronic renal disease. Subjects who were initially enrolled but did not use the allocated device (BPAP or sham BPAP) for at least 12 h daily were also excluded at a later point. All subjects enrolled were continuous airway pressure (CPAP) and BPAP naïve and had no knowledge about the BPAP apparatus prior to enrollment, and were informed in detail about the study protocol and all methods used at the time of enrollment by the primary investigators of the study. None of the subjects declared a history of sleep apnea.
All subjects underwent OBS (gastroplasty by Mason or gastric bypass) by the same operating team and were treated with the same standard anesthetic protocol (Table 1) [5, 6]. BPAP (Respironics Inc., Murrysville, PA, USA) or sham BPAP was applied immediately after transfer to the recovery unit and for 3 days postoperatively. BPAP was applied for at least 12 h day-1, subjects being suggested to use it for 2 h every 3 h.
Subjects were assigned to the following two study groups postoperatively:
1. Sham BPAP (control) group in which sham BPAP was applied through a nasal mask for 3 days postoperatively.
2. BPAP group in which BPAP through a nasal mask, at individualized IPAP/EPAP pressures, was applied for 3 days postoperatively.
Assignment to each study group was performed randomly using sealed envelopes by an external investigator belonging to a different department and hospital, who was totally unaware of the study protocol as well as patient demographics and background. Patient monitoring and documentation of pulmonary function was performed by a distinct team of anesthesiologists unaware of the study protocol.
IPAP and EPAP in the BPAP system were individualized for each subject by using acceptable values of SpO2, PaCO2, and patient synchronization and tolerability with the device as criteria for the personalization of the parameters used in the ward.
This individualized setting of pressures in the BPAP group was applied gradually starting with 12/4 cm H2O (1.2/0.4 kPa) (IPAP/EPAP) and up to 18/10 cm H2O (1.8/1.0 kPa) (IPAP/EPAP) with consecutive increases of 2 cm H2O, according to a previous study [10].
Sham BPAP was created by introducing a hole at the connection of the mask with the spiral tube of the BPAP. With this modality, also used in previous studies, the applied pressure by sham BPAP was constant and equal to 2 cm H2O (0.2 kPa) [12, 13]. Supplemental oxygen at 2-5 L min-1 was administered in all subjects while on and off BPAP and sham BPAP if needed, in order to keep SpO2 > 93%, as measured by pulse oximetry.
After surgery, subjects were kept at the recovery unit for two hours. During that period they were stabilized with the non-invasive positive pressure (NIPPV) system and were connected to a patient-controlled analgesia device (Table 1). Intensity of pain was assessed by a numerical rating scale (NRS) in which 0 = no pain, 10 = worst pain imaginable, and was < 4 before discharge from the recovery unit [14]. Subjects were kept at the post-anaesthesia care unit (PACU) for 24 h postoperatively and were subsequently transferred to general surgery wards. All subjects were kept on basic cardiopulmonary monitoring throughout the study period.
Pulmonary function was assessed by spirometry (spirometer MicroLab 3300, Micro Medical) 24 h before surgery and at 24, 48 and 72 h postope­ratively. Subjects were off BPAP, breathing room air, half an hour before spirometry. Intensity of postoperative pain was also recorded immediately before spirometry. Blood gas analysis (including measuring pH, PO2, PCO2, HCO3 and SaO2) was performed at the same conditions and time. Assessment was performed as single measurements at exactly 12:00 noon and no significant mouth leak was observed during the time of measurements.
Vital signs (respiratory frequency, blood pressure, heart rate and temperature), opioid consumption and fluid balance were recorded by the nursing staff every hour for the first 8 hours postoperatively, every three hours for the first 24 h and every six hours for the next 2 days. All subjects with aggravation of respiratory function and/or reporting dyspnea were further investigated for postoperative respiratory complications (hypoxemia, atelectasis combined with RDS symptoms, respiratory tract infection) with preoperative chest X-ray (CXR) as a reference.
All CXRs were diagnosed by an on call radiology attending physician who was also unaware of the study protocol and were scored for manifestation of atelectasis using a specific scoring system, as follows: 0 – normal; 1a – one-third of hemidiaphragm obscured; 1b – two-thirds of hemidiaphragm obscured; 1c – all of hemidiaphragm obscured; 2 – lobar consolidation; 3 – lobar collapse with consolidation, volume loss, and tracheal deviation; and 4 – bronchial consolidation (whole lung collapse).
Hypoxemia was considered as SpO2 < 90% and duration of hospitalization was also recorded for all subjects.
All subjects were encouraged to mobilize as soon as possible and had sessions of respiratory physiotherapy twice daily, consisting of manual techniques to enable chest clearance and the use of the Triflo II Inspiratory Exerciser, a flow-oriented, 3-ball incentive spirometer incentive spirometer device (Teleflex Medical, Inc, USA), while off BPAP or sham BPAP system.

Statistical analysis

Sample size was calculated using the Do-It-Yourself (DIY) quantitative research sample size calculator (available online at: https://blog.flexmr.net/sample-size-calculator) by considering a confidence level of 95% and a 10% margin of error. Continuous variables were expressed as mean ± standard deviation (SD) and non-continuous variables as absolute frequencies and percentages. Continuous variables were assessed for distribution normality graphically (by histograms and box plots) and statistically using the Kolmogorov-Smirnov test. Differences of continuous variables among repeated examinations were evaluated by ANOVA for repeated measures and post-hoc analysis for multiple paired comparisons was performed using Bonferroni correction. Chi-square and Fisher exact test, when appropriate, were used to evaluate differences of non-continuous (i.e. categorical) variables between repeated examination sessions. A P-value lower than 0.05 indicated statistical significance. Statistical analysis was performed using IBM SPSS Statistics software version 19 (IBM Corp, Chicago, IL, USA).

Results

Thirty-five individuals were eventually analyzed in the present study, 21 in the BPAP and 14 in the sham BPAP group, as shown in the CONSORT flow diagram (Figure 1). Subjects excluded due to non-compliance were retrospectively interviewed. Two subjects excluded from the BPAP group reported discomfort with device application and one patient reported a subjective feeling of not being helped by the intervention. From the sham BPAP group 5 subjects reported discomfort with device application and 4 reported a subjective feeling of not being helped. Arterial blood gas (ABG) analysis and spirometric indices (pre- and postoperatively) did not differ significantly for these subjects compared with the rest of subjects in the corresponding group, demonstrating that there was no actual danger of iatrogenic damage to control subjects.
Baseline characteristics and FVC, FEV1, PEFR, SpO2 and ABG values (pH, pCO2, pO2, HCO3) did not differ significantly between study groups preope­ratively (Tables 2-4). The mean pressures applied in the BPAP group were 15 ± 2/8 ± 2 cm H2O (1.5 ± 0.2/0.8 ± 0.2 kPa) (IPAP/EPAP) for the total duration of device use. On the 1st post-operative day, an average of 12 ± 0/4 ± 0 cm H2O (1.2 ± 0/0.4 ± 0 kPa) (IPAP/EPAP), on the 2nd post-operative day an average of 15 ± 2/8 ± 2 cm H2O (1.5 ± 0.2/0.8 ± 0.2 kPa) (IPAP/EPAP) and on the 3rd post-operative day an average of 18 ± 4/9 ± 3 cm H2O (1.8 ± 0.4/0.9 ± 0.3 kPa) (IPAP/EPAP) was reached. Daily average duration of use of BPAP and sham BPAP was similar for both groups (Table 4).
Postoperatively pulmonary function deteriorated significantly in both groups as indicated by FVC, FEV1, PEFR and SpO2 values with gradual improvement in the following days (Figures 2-5). Subjects in the BPAP group showed in general better spirometric performance postoperatively (Table 4) as well as better SpO2 and pO2 values compared with subjects in the sham BPAP group. Postoperative pulmonary recovery was also accelerated in the BPAP treated group (Figures 2-5).
Regarding respiratory complications five subjects from the sham BPAP group (33%), three after gastric-bypass (3 from 4 subjects – 75%) and two after gastroplasty (2 from 10 subjects – 20%) developed hypoxemia during mobilization on the first postoperative day. Three of the above subjects (21%) had chest radiography findings (all with a radiographic score of 1 on post-operative days 1 and 2) consistent with atelectasis (Table 4) and one of them submitted to gastroplasty presented with fever, leukocytosis and productive cough on the third postoperative day and with chest X-ray findings (radiographic score 2) consistent with lower respiratory tract infection. All cases of hypoxemia were treated by administration of O2 (mean administration rate of 3 L min-1 and mean duration of treatment of 6 hours day-1), respiratory physiotherapy and antibiotics, where needed. None of the subjects in the BPAP group presented with respiratory complications.
Pain scores were similar for both groups postoperatively (Table 4) as well as opioid consumption. The hospitalization time also did not differ significantly between groups and was 5-7 days after gastroplasty and 9-11 days after gastric bypass with the exception of the patient diagnosed with lower respiratory tract infection, who was hospitalized for 9 days.
We computed (post-hoc) the observed power of the performed tests (ANOVA for repeated measures). We confirmed that the specific sample size yielded adequate statistical power (> 80%) for each of the examined variables.

Discussion

The detrimental effects of obesity on pulmonary function are well defined and are further aggravated by abdominal surgery [1]. Today there is no evidence that intraoperative manipulations, such as alveolar recruitment and positive end-expiratory pressure (PEEP), may improve postoperative hypoxemia while postoperative application of NIPPV, with the use of CPAP and BPAP, has proved to have beneficial effects [10, 11, 15, 16].
In previous studies in MOP undergoing OBS, BPAP was applied at fixed pressures for 24 h postoperatively while control groups received oxygen through a simple face mask or nasal cannula and BPAP application was accompanied by significant improvement of FEV1, FVC and SpO2 for three days postoperatively in relation to the control group [10, 11].
In our study BPAP was applied for three days postoperatively assuming that the diaphragmatic dysfunction caused by abdominal surgery, the use of opioids for analgesia and the limited mobilization continue to affect pulmonary function beyond 24 h postoperatively. Our choice of prolonged BPAP application was also based on the temporal pattern of postoperative pulmonary complications that usually appear after the 2nd and 3rd postoperative day and our decision was also supported by the results of a preliminary pilot study, where the mean time for full mobilization of subjects was three days.
In contrast with previous studies, BPAP was applied at individualized pressures in our study and not at fixed pressures in order for subjects to take most advantage of respiratory support since a simple pressure setting could have been suboptimal for some subjects [10, 11]. Sham BPAP, created by introducing a hole at the connection of the mask with the spiral tube of BPAP, was also used to neutralize any placebo device related effects and in order to minimize bias from attending physicians and subjects, and, even if this could be seen as a minor limitation of the present study, due to subjective manipulation of the BPAP device, this is the first study to use sham BPAP in MOP undergoing OBS [12, 14].
According to our findings, application of BPAP at individualized pressures, for three days postoperatively, significantly alleviated the postoperative restrictive lung disease in relation to sham BPAP. In the BPAP group values of FEV1 and FVC were significantly higher on the second and third postoperative day compared with the sham BPAP group and SpO2 values were significantly better for all three postoperative days. The small sample size in both groups, although calculated to provide adequate statistical power, has to be seen as a limitation of the present study. Low tolerance of the BPAP device, which led to the exclusion of some subjects from the study, may be seen as another limitation. Our results are similar to those of Ebeo [10] and Joris [11] from the qualitative point of view only and not completely comparable since our sample of morbidly obese patients contained a high percentage of smokers (66.6% in the BPAP group vs. 47.7% in the sham BPAP group). From the above point of view, even if smoking is considered to be a confounding factor in clinical studies, the observed beneficial effect of BPAP in our study is more pronounced given the additional burden imposed by smoking in our population sample, and our findings not only strengthen the findings of previous studies but also expand them, since we investigated a population with a high proportion of smokers.
Application of BPAP at individualized pressures also nullified postoperative respiratory complications and especially atelectasis and a trend for earlier patient mobilization was also observed. Additionally, from the 2nd postoperative day subjects reached the minimum required time (12 h) on BPAP that was set in our study mainly using the apparatus during sleep and resting in bed, so that the NIPPV use did not prevent full patient mobilization.
Slower recovery of respiratory function in the control group with prolongation of postoperative atelectasis, delayed mobilization, and possibly late diaphragmatic dysfunction, seem to be in the basis of the recorded complications in the control group of subjects. Type of surgery, namely open gastric bypass, was associated with greater postoperative pulmonary dysfunction in our study and, as expected, with longer hospitalization time. Application of ΒPAP was not accompanied by shorter hospitalization time with the exception of one patient in the sham BPAP group, diagnosed with lower respiratory tract infection, who was hospitalized for longer (9 days). It should be noted though, given the increasing numbers of patients subjected to bariatric surgery, that this probably represents an important finding that would have resulted in significant reduction of hospitalization time in a larger sample of subjects.
Smoking in concert with morbid obesity and postoperative status seem to account for the observed high rates of atelectasis combined with RDS symptoms in the sham BPAP group. Unfortunately previous analogous studies did not provide data regarding respiratory complications in general and atelectasis in particular, although the percentage of smokers has been significantly lower in their population samples [10, 11]. MOP undergoing surgery are at extremely high risk for developing pulmonary atelectasis combined with RDS symptoms and the high rates observed in our study are comparable with those reported by other studies that specifically examined postoperative atelectasis in MOP undergoing surgery [17, 18]. In this setting BPAP application had a significant effect since it completely attenuated atelectasis combined with RDS symptoms when applied, and this is important given the ongoing debate about the efficacy and effect on real patient outcome of interventions applied in order to improve postoperative respiratory function of MOP [2].
Application of higher pressures in our study, compared with those in previous studies, was not accompanied by significant complications such as gastric distension or leakage from the anastomosis, although the small population sample, comparable with that of previous relevant studies though, precludes the drawing of definitive conclusions [19, 20].
In conclusion, BPAP applied at individualized IPAP/EPAP pressures expedites recovery of postoperative respiratory function and eliminates pulmonary complications in MOP who have undergone OBS. Higher BPAP pressures seem also to be well tolerated by patients. Finally, this is the first study using a sham BPAP system in MOP undergoing OBS allowing neutralization of confounding factors related to device application and researcher bias.

Acknowledgements

1. Financial support and sponsorship: Department of Anesthesiology, Evangelismos General Hospital, Athens, Greece.
2. Conflict of interest: none.

References

1. Littleton SW. Impact of obesity on respiratory function. Respirology 2012; 17: 43-49. doi: 10.1111/j.1440-1843.2011.02096.x.
2. Hans GA, Lauwick S, Kaba A, Brichant JF, Joris JL. Postoperative respiratory problems in morbidly obese patients. Acta Anaesthesiol Belg 2009; 60: 169-175.
3. Vassilakopoulos T, Mastora Z, Katsaounou P, et al. Contribution of pain to inspiratory muscle dysfunction after upper abdominal surgery: a randomized control trial. Am J Respir Crit Care Med 2000; 161 (4 Pt 1): 1372-1375.
4. Cullen A, Ferguson A. Perioperative management of the severely obese patient: a selective pathophysiological review. Can J Anaesth 2012; 59: 974-996. doi: 10.1007/s12630-012-9760-2.
5. Casati A, Putzu M. Anaesthesia in the obese patient: pharmacokinetic considerations. J Clin Anaesth 2005; 17: 134-145. doi: 10.1016/j.jclinane.2004.01.009.
6. Charghi R, Backman S, Christou N, Rouah F, Schricker T. Patient controlled i.v. analgesia is an acceptable pain management strategy in morbidly obese patients undergoing gastric bypass surgery: a retrospective comparison with epidural analgesia. Can J Anaesth 2003; 50: 672-678. doi: 10.1007/BF03018709.
7. Nguyen NT, Lee SL, Goldman C, et al. Comparison of pulmonary function and postoperative pain after laparoscopic versus open gastric bypass: a randomized trial. J Am Coll Surg 2001; 192: 469-476; discussion 476-477.
8. Ambrosino N, Gabbrielli L. Physiotherapy in the perioperative period. Best Pract Res Clin Anaesthesiol 2010; 24: 283-289.
9. Moritz F, Brousse B, Gellée B, et al. Continuous positive airway pressure versus bilevel noninvasive ventilation in acute cardiogenic pulmonary edema: a randomized multicenter trial. Ann Emerg Med 2007; 50: 666-675, 675.e1. doi: 10.1016/j.annemergmed.2007.06.488.
10. Joris JL, Sottiaux TM, Chiche JD, Desaive CJ, Lamy ML. Effect of bi-level positive airway pressure (Bi-PAP) nasal ventilation on the postoperative pulmonary restrictive syndrome in obese patients undergoing gastroplasty. Chest 1997; 111: 665-670. doi: 10.1378/chest.111.3.665.
11. Ebeo CT, Benotti PN, Byrd RP Jr, Elmaghraby Z, Lui J. The effect of bi-level positive airway pressure on postoperative pulmonary function following gastric surgery for obesity. Respir Med 2002; 96: 672-676. doi: 10.1378/chest.111.3.665.
12. Soroksky A, Stav D, Shpirer I. A pilot prospective randomized placebo-controlled trial of bilevel positive airway pressure in acute asthmatic attack. Chest 2003; 123: 1018-1025. doi: 10.1378/chest.123.4.1018.
13. Thys F, Roeseler J, Reynaert M, Liistro G, Rodenstein DO. Noninvasive ventilation for acute respiratory failure: a prospective randomized placebo-controlled trial. Eur Respir J 2002; 20: 545-555.
14. Jensen MP, Karoly P. Self-report scales and procedures for assessing pain in adults. In: Turk DC, Melzak R (eds.). Hand-book of pain assessment. Guilford Press, New York 2001: 19-44.
15. Lumb AB, Greenhill SJ, Simpson MP, Stewart J. Lung recruitment and positive airway pressure before extubation does not improve oxygenation in the post-anaesthesia care unit: a randomized clinical trial. Br J Anaesth 2010; 104: 643-647. doi: 10.1093/bja/aeq080.
16. Wong DT, Adly E, Ip HY, Thapar S, Maxted GR, Chung FF. A comparison between the Boussignac™ continuous positive airway pressure mask and the venturi mask in terms of improvement in the PaO2/F(I)O2 ratio in morbidly obese patients undergoing bariatric surgery: a randomized controlled trial. Can J Anaesth 2011; 58: 532-539. doi: 10.1007/s12630-011-9497-3.
17. Talab H, Zabani IA, Abdelrahman HS, et al. Intraoperative ventilatory strategies for prevention of pulmonary atelectasis in obese patients undergoing laparoscopic bariatric surgery. Anesth Analg 2009; 109: 1511-1516. doi: 10.1213/ANE.0b013e3181ba7945.
18. Eichenberger AS, Proietti S, Wicky S, et al. Morbid obestity and postoperative pulmonary atelectasis: an underestimated problem. Anasth Analg 2002; 95: 1788-1792.
19. Ramirez A, Lalor PF, Szomstein S, Rosenthal RJ. Continuous positive airway pressure in immediate postoperative period after laparoscopic Roux-en-Y gastric bypass: is it safe? Surg Obes Relat Dis 2009; 5: 544-546. doi: 10.1016/j.soard.2009.05.007.
20. Vasquez TL, Hoddinott K. A potential complication of bi-level positive airway pressure after gastric bypass surgery. Obes Surg 2004; 14: 282-284. doi: 10.1381/096089204322857717.
This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
© 2024 Termedia Sp. z o.o.
Developed by Bentus.