twitter
en POLSKI
eISSN: 2719-3209
ISSN: 0023-2157
Klinika Oczna / Acta Ophthalmologica Polonica
Current issue Archive Videos Articles in press About the journal Supplements Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
2/2018
vol. 120
 
Share:
Share:
abstract:
Review paper

The role of integrins in eye diseases

Justyna Żaworonek
,
Beata Żelazowska-Rutkowska
,
Anna Bryl
,
Małgorzata Mrugacz
,
Bogdan Cylwik

Online publish date: 2018/10/25
View full text Get citation
 
PlumX metrics:
Integrins belong to the cell adhesion molecules. Integrins and their ligands play the main role in physiological and pathological processes: cell migration, cell differentiation, hemostasis, adhesion, angiogenesis and wound healing. The main task of integrin is to facilitate biochemical and mechanical signal transmission across the plasma membrane in a bidirectional manner. The sig­nals trigger integrin transformation from an inactive form into a ligand-binding state. Integrins play an important role in physiological (embryogenesis, tissue growth and development) and pathological (allergy, inflammation, cancer) processes, being particularly involved in dry eye disease, age-related macular degeneration and diabetic macular edema. Improved understanding of integrins can contribute to the development of new diagnostic methods and advances in immunotherapy.
keywords:

integrins α and β, eye diseases, adhesion molecules, ligand

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.