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eISSN: 2719-3209
ISSN: 0023-2157
Klinika Oczna / Acta Ophthalmologica Polonica
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1/2006
vol. 108
 
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abstract:
Review article

The role of nitric oxide in physiology and pathogenesis of ocular diseases

Katarzyna Komaszyło
1, 2
,
Renata Zalewska
1
,
Zofia Mariak
1
,
Róża Julia Wiśniewska
2

  1. Z Kliniki Okulistyki Akademii Medycznej w Białymstoku
  2. Z Zakładu Farmakologii Akademii Medycznej w Białymstoku
Online publish date: 2006/03/17
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Nitric oxide (NO) is a gas with diverse biological activities produced from arginine by nitric oxide synthetase (NOS). The loss of retinal ganglion cells is a hallmark of many ophthalmic diseases including glaucoma, retinal ischemia due to central artery occlusion and anterior ischemic optic neuropathy. It may well be significant in optic neuritis, optic nerve, trauma and AIDS. NO appears to be involved in the regulation of intraocular pressure, in the modulation of ocular blood flow and in apoptosis. This article gives a short and simplified overview of the biochemistry of NO and its role in physiology and pathogenesis of ocular diseases.
keywords:

nitric oxide, glutamate, retinal ganglion cell, neuroprotection

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