The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review

Valentina Lancellotta; Francesca Felice; Lisa Vicenzi; Alfredo Antonacci; Valentina Cerboneschi; Sara Costantini; Daniela Cristino; Luca Tagliaferri; Annamaria Cerrotta; Andrea Vavassori; Sergio Gribaudo; Alessandro Colombo; Francesco Lucà; Raffaele Barbara; Monica Mangoni; Francesco Marampon; Daniela Musio; Filippo Bellati; Francesco Torcia; Vincenzo Tombolini; Mattia Falchetto; Vitaliana De Sanctis

doi:10.5114/jcb.2020.92698

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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abstract:

Review paper

The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review

Valentina Lancellotta

¹

,

Francesca De Felice

²

,

Lisa Vicenzi

³

,

Alfredo Antonacci

⁴

,

Valentina Cerboneschi

⁵

,

Sara Costantini

³

,

Daniela di Cristino

⁶

,

Luca Tagliaferri

¹

,

Annamaria Cerrotta

⁷

,

Andrea Vavassori

⁸

,

Sergio Gribaudo

⁹

,

Alessandro Colombo

¹⁰

,

Francesco Lucà

¹¹

,

Raffaele Barbara

¹²

,

Monica Mangoni

¹³

,

Francesco Marampon

²

,

Daniela Musio

²

,

Filippo Bellati

¹⁴

,

Francesco Torcia

¹⁴

,

Vincenzo Tombolini

²

,

Mattia Falchetto

¹⁵

,

Vitaliana De Sanctis

¹⁵

Fondazione Policlinico Universitario A. Gemelli IRCCS, Dipartimento di Diagnostica per immagini, Radioterapia Oncologica ed Ematologia – Gemelli ART (Advanced Radiation Therapy), Interventional Oncology Center (IOC), Roma, Italy
Department of Radiological, Oncological and Anatomo Pathological Sciences, Azienda Ospedaliero Universitaria Policlinico Umberto I, “Sapienza” University, Rome, Italy
Radiotherapy Unit, Azienda Ospedaliero Universitaria Ospedali Riuniti, Ancona, Italy
Radiotherapy Unit, S. Spirito Hospital, Pescara, Italy
Radiotherapy Unit, Department of Oncology, San Luca Hospital, Lucca, Italy
Radiotherapy Unit, Presidio Ospedaliero San Filippo Neri, Roma, Italy
Radiotherapy Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
Division of Radiotherapy, IEO European Institute of Oncology, IRCCS, Milan, Italy
Department of Oncology-Radiotherapy, A.O.U. Città della Salute e della Scienza di Torino, Turin, Italy
Division of Radiation Oncology, ASST-Lecco, Ospedale A.Manzoni, Lecco, Italy
Presidente Fondazione Area Radiologica, Roma, Italy
UOC Radioterapia Oncologica, Azienda Ospedaliera “Brotzu”, Cagliari, Italy
Radiotherapy Unit, Dipartimento di Scienze Biomediche, Sperimentali e Cliniche Mario Serio, University of Florence, Firenze, Italy
Department of Medicine and Surgery and Translational Medicine, Gynecology Unit, Sant’ Andrea University Hospital, “Sapienza” University, Rome, Italy
Department of Medicine and Surgery and Translational Medicine, Radiotherapy Oncology, Sant’ Andrea Hospital, “Sapienza” University, Rome, Italy

J Contemp Brachytherapy 2020; 12, 1: 61–66

DOI: https://doi.org/10.5114/jcb.2020.92698

Online publish date: 2020/02/28

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AMA

Lancellotta V, Felice FD, Vicenzi L, et al. The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review. Journal of Contemporary Brachytherapy. 2020;12(1):61-66. doi:10.5114/jcb.2020.92698.

APA

Lancellotta, V., Felice, F. D., Vicenzi, L., Antonacci, A., Cerboneschi, V.,  & Costantini, S. et al. (2020). The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review. Journal of Contemporary Brachytherapy, 12(1), 61-66. https://doi.org/10.5114/jcb.2020.92698

Chicago

Lancellotta, Valentina, Francesca D Felice, Lisa Vicenzi, Alfredo Antonacci, Valentina Cerboneschi, Sara Costantini,  and Daniela D Cristino et al. 2020. "The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review". Journal of Contemporary Brachytherapy 12 (1): 61-66. doi:10.5114/jcb.2020.92698.

Harvard

Lancellotta, V., Felice, F., Vicenzi, L., Antonacci, A., Cerboneschi, V., Costantini, S., Cristino, D., Tagliaferri, L., Cerrotta, A., Vavassori, A., Gribaudo, S., Colombo, A., Lucà, F., Barbara, R., Mangoni, M., Marampon, F., Musio, D., Bellati, F., Torcia, F., Tombolini, V., Falchetto, M.,  and De Sanctis, V. (2020). The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review. Journal of Contemporary Brachytherapy, 12(1), pp.61-66. https://doi.org/10.5114/jcb.2020.92698

MLA

Lancellotta, Valentina et al. "The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review." Journal of Contemporary Brachytherapy, vol. 12, no. 1, 2020, pp. 61-66. doi:10.5114/jcb.2020.92698.

Vancouver

Lancellotta V, Felice F, Vicenzi L, Antonacci A, Cerboneschi V, Costantini S et al. The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review. Journal of Contemporary Brachytherapy. 2020;12(1):61-66. doi:10.5114/jcb.2020.92698.

Purpose
Serous adenocarcinoma (uterine serous carcinoma – USC) is a rare and aggressive histologic subtype of endometrial cancer, with a high-rate of recurrence and poor prognosis. The adjuvant treatment for stage I patients is unclear. The purpose of this study was to evaluate the outcomes of stage I USC treated exclusively with chemotherapy plus vaginal brachytherapy (VBT).

Material and methods
A systematic research using PubMed, Scopus, and Cochrane library was conducted to identify full articles evaluating the efficacy of VBT in patients with stage I USC. A search in ClinicalTrials.gov was performed in order to detect ongoing or recently completed trials, and in PROSPERO for searching ongoing or recently completed systematic reviews.

Results
All studies were retrospective and 364 of evaluated patients were found. The average local control was 97.5% (range, 91-100%), the disease free-survival was 88% (range, 82-94%), the overall survival was 93% (range, 72-100%), the specific cancer survival was 89.4% (range, 84.8-94%), and the G3-G4 toxicity was 0-8%.

Conclusions
These data support the concept that in adequately selected patients, VBT alone may be a suitable radiotherapy technique in women with stage I USC who underwent surgical staging and received adjuvant chemotherapy.

keywords:

The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review

serous adenocarcinoma, endometrial cancer, brachytherapy, outcomes