Acquired autoimmune hypothyroidism as a cause of severe growth deficiency in one of the twin sisters

Andrzej Kędzia; Katarzyna Majewska

doi:10.5114/pedm.2019.87713

eISSN: 2083-8441
ISSN: 2081-237X

Pediatric Endocrinology Diabetes and Metabolism

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abstract:

Case report

Acquired autoimmune hypothyroidism as a cause of severe growth deficiency in one of the twin sisters

Andrzej Kędzia

¹

,

Katarzyna A. Majewska

¹

Department of Clinical Auxology and Pediatric Nursing, Poznan University of Medical Sciences, Po-land

Pediatr Endocrinol Diabetes Metab 2019; 25 (3): 163-167

DOI: https://doi.org/10.5114/pedm.2019.87713

Online publish date: 2019/09/24

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Acquired autoimmune hypothyroidism is rare in early childhood, however, it must be considered in a 4 year old child with medical his-tory of delayed growth, increased somnolence, difficulty concentrating, and reduced activity. We report on the case of full clinical picture of severe hypothyroidism in one of the twins. Thyroid function deteriorated in one of the sisters, resulting in mental, motor and growth slowdown, remaining undiagnosed for about 2 years, while the other sister developed normally. In the reported case, severe hypothy-roidism and growth deficiency were accompanied by celiac disease. Initiation of L-thyroxine therapy resulted in an immediate response that increased the growth velocity by more than 2.2 times. This confirms the dominant role of thyroid hormones over celiac disease in the growth process, as the catch up effect started before gluten free diet was introduced.

keywords:

Acquired autoimmune hypothyroidism as a cause of severe growth deficiency in one of the twin sisters

Andrzej Kędzia 1 , Katarzyna A. Majewska 1

hypothyroidism, growth deficiency, children

Andrzej Kędzia

¹

,

Katarzyna A. Majewska

¹