Glioblastoma multiforme - the latest treatment options

Aleksandra Orzechowska; Julia Orzechowska; Karolina Ziętara; Mateusz Pawlina; Natalia Pawełczak; Aleksander Oskroba; Cezary Stawikowski; Karolina Raksa; Ilona Kowalczyk; Bartłomiej Zielonka; Piotr Pawłowski

doi:10.19251/pwod/2023.3(2)

eISSN: 2544-2538
ISSN: 2450-8624

Pielęgniarstwo w Opiece Długoterminowej / Long-Term Care Nursing

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3/2023
vol. 8

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abstract:

Original paper

Glioblastoma multiforme - the latest treatment options

Aleksandra Orzechowska

¹

,

Julia Orzechowska

²

,

Karolina Ziętara

¹

,

Mateusz Pawlina

¹

,

Natalia Pawełczak

¹

,

Aleksander Oskroba

¹

,

Cezary Stawikowski

³

,

Karolina Raksa

¹

,

Ilona Kowalczyk

⁴

,

Bartłomiej Zielonka

³

,

Piotr Pawłowski

¹

Faculty of Medicine, Medical University of Lublin, Polska
Faculty of Dentistry, Medical University od Lublin, Polska
Resident, 1st Military Clinical Hospital in Lublin, Polska
Resident, Independent Public Clinical Hospital prof. W. Orlowski CMKP in Warsaw, Polska

Long-Term Care Nursing 2023; 8 (3): 8-17

DOI: https://doi.org/10.19251/pwod/2023.3(2)

Online publish date: 2023/11/02

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Background
Primary brain tumors account for up to 2% of all malignancies. Of these, glioblastoma multiforme (GBM) is the most common. GBM is one of the primary tumors of the central nervous system with a very high degree of malignancy – IV according to the classification of the WHO. The survival time from diagnosis in most patients is only a dozen or so months, and the median survival is about 12 months. Only 3–8% of patients live longer than 3 years.

Aim of the study
The aim of the study is to indicate the latest treatment options for glioblastoma multiforme.

Material and methods
English-language scientific literature from 2012 - 2022 from databases such as PubMed, SCOPUS, Web of Science, Google Scholar was reviewed. Searches were conducted according to keywords: GBM, glioblastoma multiforme, immunotherapy, chemotherapy. 25 items of literature were qualified for analysis.

Results and conclusions:
Despite advances in science, glioblastoma is still not a curable disease. Large amounts are placed in molecular carriers that can cross the blood-brain barrier and reach the tumor directly. Immunotherapy is becoming an effective alternative to non-specific chemotherapy, which is also associated with fewer systemic side effects. The results of studies on the use of CAR-T therapy in the treatment of solid tumors are becoming more and more promising. What is more, nursing staff play an important role in the care of a patient with GBM.

keywords:

Glioblastoma multiforme - the latest treatment options

Aleksandra Orzechowska 1 , Julia Orzechowska 2 , Karolina Ziętara 1 , Mateusz Pawlina 1 , Natalia Pawełczak 1 , Aleksander Oskroba 1 , Cezary Stawikowski 3 , Karolina Raksa 1 , Ilona Kowalczyk 4 , Bartłomiej Zielonka 3 , Piotr Pawłowski 1

GBM, glioblastoma multiforme, immunotherapy, chemotherapy

Aleksandra Orzechowska

¹

,

Julia Orzechowska

²

,

Karolina Ziętara

¹

,

Mateusz Pawlina

¹

,

Natalia Pawełczak

¹

,

Aleksander Oskroba

¹

,

Cezary Stawikowski

³

,

Karolina Raksa

¹

,

Ilona Kowalczyk

⁴

,

Bartłomiej Zielonka

³

,

Piotr Pawłowski

¹